Fantridone HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591375

CAS#: 24390-12-3 (HCl)

Description: Fantridone HCl is a biochemical.


Chemical Structure

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Fantridone HCl
CAS# 24390-12-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 591375
Name: Fantridone HCl
CAS#: 24390-12-3 (HCl)
Chemical Formula: C18H23ClN2O2
Exact Mass: 334.1448
Molecular Weight: 334.84
Elemental Analysis: C, 64.57; H, 6.92; Cl, 10.59; N, 8.37; O, 9.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 17692-37-4 (free base)   24390-12-3 (HCl)  

Synonym: Fantridone hydrochloride; AGN 616; AGN-616; AGN616;

IUPAC/Chemical Name: 6(5H)-Phenanthridinone, 5-(3-(dimethylamino)propyl)-monohydrochloride, monohydrate

InChi Key: NYUJOGMUKNKJAT-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H20N2O.ClH.H2O/c1-19(2)12-7-13-20-17-11-6-5-9-15(17)14-8-3-4-10-16(14)18(20)21;;/h3-6,8-11H,7,12-13H2,1-2H3;1H;1H2

SMILES Code: O=c1n(CCCN(C)C)c2ccccc2c3ccccc31.Cl.O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 334.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Wang WK, Chiang WC, Lai CH, Lee CH. <i>Salmonella</i> mediated cytolethal distending toxin transfer inhibits tumor growth<i></i>. Hum Gene Ther. 2018 Jun 5. doi: 10.1089/hum.2018.030. [Epub ahead of print] PubMed PMID: 29869526.

2: Xu HL, Fan ZL, ZhuGe DL, Tong MQ, Shen BX, Lin MT, Zhu QY, Jin BH, Sohawon Y, Yao Q, Zhao YZ. Ratiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core-shell nanoparticles targeting the heterogeneous tumor cells of glioma. Drug Deliv. 2018 Nov;25(1):1302-1318. doi: 10.1080/10717544.2018.1474974. PubMed PMID: 29869524.

3: Omar SM, AbdAlla FI, Abdelgawad NM. Preparation and Optimization of Fast-Disintegrating Tablet Containing Naratriptan Hydrochloride Using D-Optimal Mixture Design. AAPS PharmSciTech. 2018 Jun 4. doi: 10.1208/s12249-018-1061-9. [Epub ahead of print] PubMed PMID: 29869307.

4: Imdad S, Chaurasia AK, Kim KK. Identification and Validation of an Antivirulence Agent Targeting HlyU-Regulated Virulence in Vibrio vulnificus. Front Cell Infect Microbiol. 2018 May 11;8:152. doi: 10.3389/fcimb.2018.00152. eCollection 2018. PubMed PMID: 29868508; PubMed Central PMCID: PMC5958221.

5: Biondo LA, Batatinha HA, Souza CO, Teixeira AAS, Silveira LS, Alonso-Vale MI, Oyama LM, Alves MJ, Seelaender M, Neto JCR. Metformin Mitigates Fibrosis and Glucose Intolerance Induced by Doxorubicin in Subcutaneous Adipose Tissue. Front Pharmacol. 2018 May 8;9:452. doi: 10.3389/fphar.2018.00452. eCollection 2018. PubMed PMID: 29867463; PubMed Central PMCID: PMC5952005.

6: Yang W, Liu W, Miao C, Sun H, Li L, Li C. Oral Glucosamine Hydrochloride Combined With Hyaluronate Sodium Intra-Articular Injection for Temporomandibular Joint Osteoarthritis: A Double-Blind Randomized Controlled Trial. J Oral Maxillofac Surg. 2018 Jun 2. pii: S0278-2391(18)30396-3. doi: 10.1016/j.joms.2018.04.031. [Epub ahead of print] PubMed PMID: 29864430.

7: Obeid A, Hsu J, Ehmann D, Gao X, Sridhar J, Chiang A, Park CH, Ho AC. TOPICAL DORZOLAMIDE-TIMOLOL WITH INTRAVITREOUS ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR FOR RETINAL VEIN OCCLUSION: A PILOT STUDY. Retin Cases Brief Rep. 2018 Jun 1. doi: 10.1097/ICB.0000000000000752. [Epub ahead of print] PubMed PMID: 29864044.

8: Natarajan S, Salmara Ganeshbhat H, Shrivastava S, Sankareswaran S, Kumar P. Atropisomerism in Rilpivirine hydrochloride: Spectroscopic characterization of Rilpivirine and related impurities. Chirality. 2018 Jun 4. doi: 10.1002/chir.22980. [Epub ahead of print] PubMed PMID: 29863761.

9: Nakajima T. [A University Approach to Promoting the Proper Formulation and Use of Hospital Preparations]. Yakugaku Zasshi. 2018;138(6):763-766. doi: 10.1248/yakushi.17-00184-3. Japanese. PubMed PMID: 29863043.

10: Morpurgo M, Barord GJ. Antibiotic Treatment of Mucodegeneration and Positive Buoyancy in a Chambered Nautilus, Nautilus Pompilius. J Aquat Anim Health. 2018 Jun 4. doi: 10.1002/aah.10032. [Epub ahead of print] PubMed PMID: 29862571.

11: Abdalla OM, Abdel-Megied AM, Saad AS, Soliman SS. Simultaneous spectrophotometric determination of compounds having relatively disparate absorbance and concentration ranges; application to antidiabetic formulation of linagliptin and metformin. Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 16;203:112-117. doi: 10.1016/j.saa.2018.05.064. [Epub ahead of print] PubMed PMID: 29860167.

12: Min F, Lirui W, Siyuan C, Pu Y. Penehyclidine hydrochloride regulates mitochondrial dynamics and apoptosis through p38MAPK and JNK signal pathways and provides cardioprotection in rats with myocardial ischemia-reperfusion injury. Eur J Pharm Sci. 2018 May 31. pii: S0928-0987(18)30248-3. doi: 10.1016/j.ejps.2018.05.023. [Epub ahead of print] PubMed PMID: 29860115.

13: Liu TT, Chen K, Wang Q. Skin drug permeability and safety through a vibrating solid micro-needle system. Drug Deliv Transl Res. 2018 Jun 1. doi: 10.1007/s13346-018-0544-2. [Epub ahead of print] PubMed PMID: 29858819.

14: Youssef SH, Hegazy MA, Mohamed D, Badawey AM. Analysis of paracetamol, pseudoephedrine and cetirizine in Allercet Cold(®) capsules using spectrophotometric techniques. Chem Cent J. 2018 Jun 1;12(1):67. doi: 10.1186/s13065-018-0436-z. PubMed PMID: 29858703.

15: Zhu S, Xi XB, Duan TL, Zhai Y, Li J, Yan YB, Yao K. The cataract-causing mutation G75V promotes γS-crystallin aggregation by modifying and destabilizing the native structure. Int J Biol Macromol. 2018 May 29. pii: S0141-8130(18)31602-7. doi: 10.1016/j.ijbiomac.2018.05.220. [Epub ahead of print] PubMed PMID: 29857103.

16: Gan BK, Yong CY, Ho KL, Omar AR, Alitheen NB, Tan WS. Targeted Delivery of Cell Penetrating Peptide Virus-like Nanoparticles to Skin Cancer Cells. Sci Rep. 2018 May 31;8(1):8499. doi: 10.1038/s41598-018-26749-y. PubMed PMID: 29855618.

17: Adeyemi WJ, Olayaki LA. Diclofenac - induced hepatotoxicity: Low dose of omega-3 fatty acids have more protective effects. Toxicol Rep. 2017 Dec 16;5:90-95. doi: 10.1016/j.toxrep.2017.12.002. eCollection 2018. PubMed PMID: 29854580; PubMed Central PMCID: PMC5977161.

18: Rezazadeh M, Akbari V, Amuaghae E, Emami J. Preparation and characterization of an injectable thermosensitive hydrogel for simultaneous delivery of paclitaxel and doxorubicin. Res Pharm Sci. 2018 Jun;13(3):181-191. doi: 10.4103/1735-5362.228918. PubMed PMID: 29853928; PubMed Central PMCID: PMC5921399.

19: Zhang X, Hu F, Liu C, Yin L, Zhang Y, Zhang Y, Lan X. Evaluation of (99m)Tc-HYNIC-VCAM-1(scFv) as a Potential Qualitative and Semiquantitative Probe Targeting Various Tumors. Contrast Media Mol Imaging. 2018 May 3;2018:7832805. doi: 10.1155/2018/7832805. eCollection 2018. PubMed PMID: 29853809; PubMed Central PMCID: PMC5960529.

20: Pedrote MM, de Oliveira GAP, Felix AL, Mota MF, Marques MA, Soares IN, Iqbal A, Norberto DR, Gomes AMO, Gratton E, Cino EA, Silva JL. Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer. J Biol Chem. 2018 May 31. pii: jbc.RA118.003285. doi: 10.1074/jbc.RA118.003285. [Epub ahead of print] PubMed PMID: 29853637.