L 743310

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596701

CAS#: 187724-86-3

Description: L 743310 is a neurokinin-1 receptor antagonist.


Price and Availability

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L 743310 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596701
Name: L 743310
CAS#: 187724-86-3
Chemical Formula: C30H33BrF6N4O2
Exact Mass:
Molecular Weight: 675.51
Elemental Analysis: C, 53.34; H, 4.92; Br, 11.83; F, 16.87; N, 8.29; O, 4.74


Synonym: L 743310; L-743310; L743310; L-743,310; L 743,310; L743,310;

IUPAC/Chemical Name: 4-(3-(5-(3,5-bis(trifluoromethyl)phenyl)-1-(1H-indol-3-yl)-3-oxopentan-2-yl)ureido)-1-methylquinuclidin-1-ium bromide

InChi Key: AQFXPXNYLQHPJX-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H32F6N4O2.BrH/c1-40-11-8-28(9-12-40,10-13-40)39-27(42)38-25(16-20-18-37-24-5-3-2-4-23(20)24)26(41)7-6-19-14-21(29(31,32)33)17-22(15-19)30(34,35)36;/h2-5,14-15,17-18,25,37H,6-13,16H2,1H3,(H-,38,39,42);1H

SMILES Code: O=C(NC12CC[N+](CC2)(C)CC1)NC(C(CCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O)CC4=CNC5=C4C=CC=C5.[Br-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Laird JM, Roza C, De Felipe C, Hunt SP, Cervero F. Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice. Pain. 2001 Feb 1;90(1-2):97-103. PubMed PMID: 11166975.

2: Robichaud A, Tattersall FD, Choudhury I, Rodger IW. Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret. Neuropharmacology. 1999 Feb;38(2):289-97. PubMed PMID: 10218871.

3: Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM, Ladduwahetty T, Keown L, Swain C, Baker R, Cascieri M, Ber E, Metzger J, MacIntyre DE, Hill RG, Hargreaves RJ. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996;35(8):1121-9. PubMed PMID: 9121615.