L 741671

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596700

CAS#: 187724-85-2

Description: L 741671 is a neurokinin-1 receptor antagonist.


Price and Availability

Size
Price

Size
Price

Size
Price

L 741671 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 596700
Name: L 741671
CAS#: 187724-85-2
Chemical Formula: C23H22F6N4O2
Exact Mass: 500.1647
Molecular Weight: 500.44
Elemental Analysis: C, 55.20; H, 4.43; F, 22.78; N, 11.20; O, 6.39


Synonym: L 741671; L-741671; L741671; L-741,671; L 741,671; L741,671;

IUPAC/Chemical Name: 5-(((2R,3R)-3-((3,5-bis(trifluoromethyl)benzyl)oxy)-2-phenylpiperidin-1-yl)methyl)-1,2-dihydro-3H-1,2,4-triazol-3-one

InChi Key: ZUWHBRRBKKTMQO-UYAOXDASSA-N

InChi Code: InChI=1S/C23H22F6N4O2/c24-22(25,26)16-9-14(10-17(11-16)23(27,28)29)13-35-18-7-4-8-33(12-19-30-21(34)32-31-19)20(18)15-5-2-1-3-6-15/h1-3,5-6,9-11,18,20H,4,7-8,12-13H2,(H2,30,31,32,34)/t18-,20-/m1/s1

SMILES Code: O=C1NNC(CN2[C@H](C3=CC=CC=C3)[C@H](OCC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)CCC2)=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM, Ladduwahetty T, Keown L, Swain C, Baker R, Cascieri M, Ber E, Metzger J, MacIntyre DE, Hill RG, Hargreaves RJ. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996;35(8):1121-9. PubMed PMID: 9121615.