L-767685

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596699

CAS#: 183745-58-6

Description: L-767685 is a bioactive chemical.


Price and Availability

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L-767685 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596699
Name: L-767685
CAS#: 183745-58-6
Chemical Formula: C22H28N4O4
Exact Mass: 412.2111
Molecular Weight: 412.49
Elemental Analysis: C, 64.06; H, 6.84; N, 13.58; O, 15.51


Synonym: L-767685; L 767685; L767685;

IUPAC/Chemical Name: ethyl (S)-3-(2-(1-oxo-7-(piperazin-1-yl)-3,4-dihydroisoquinolin-2(1H)-yl)acetamido)pent-4-ynoate

InChi Key: NVENYTWRUWFLAR-QGZVFWFLSA-N

InChi Code: InChI=1S/C22H28N4O4/c1-3-17(13-21(28)30-4-2)24-20(27)15-26-10-7-16-5-6-18(14-19(16)22(26)29)25-11-8-23-9-12-25/h1,5-6,14,17,23H,4,7-13,15H2,2H3,(H,24,27)/t17-/m1/s1

SMILES Code: C#C[C@@H](NC(CN1C(c2c(CC1)ccc(N3CCNCC3)c2)=O)=O)CC(OCC)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Philipps RR, Xu X, Mills GL, Bringolf RB. Impact of natural organic matter and increased water hardness on DGT prediction of copper bioaccumulation by yellow lampmussel (Lampsilis cariosa) and fathead minnow (Pimephales promelas). Environ Pollut. 2018 Jun 1;241:451-458. doi: 10.1016/j.envpol.2018.05.059. [Epub ahead of print] PubMed PMID: 29864748.

2: Khandaker S, Toyohara Y, Kamida S, Kuba T. Effective removal of cesium from wastewater solutions using an innovative low-cost adsorbent developed from sewage sludge molten slag. J Environ Manage. 2018 Jun 1;222:304-315. doi: 10.1016/j.jenvman.2018.05.059. [Epub ahead of print] PubMed PMID: 29864743.

3: Jin B, Niu J, Dai J, Li N, Zhou P, Niu J, Zhang J, Tao H, Ma Z, Zhang Z. New insights into the enhancement of biochemical degradation potential from waste activated sludge with low organic content by Potassium Monopersulfate treatment. Bioresour Technol. 2018 May 18;265:8-16. doi: 10.1016/j.biortech.2018.05.032. [Epub ahead of print] PubMed PMID: 29864736.

4: Ma SJ, Ding LL, Hu HD, Ma HJ, Xu K, Huang H, Geng JJ, Ren HQ. Cell membrane characteristics and microbial population distribution of MBBR and IFAS with different dissolved oxygen concentration. Bioresour Technol. 2018 Mar 30;265:17-24. doi: 10.1016/j.biortech.2018.03.111. [Epub ahead of print] PubMed PMID: 29864733.

5: Lin WY, Ng WC, Wong BSE, Teo SL, Sivananthan GD, Baeg GH, Ok YS, Wang CH. Evaluation of sewage sludge incineration ash as a potential land reclamation material. J Hazard Mater. 2018 May 23;357:63-72. doi: 10.1016/j.jhazmat.2018.05.047. [Epub ahead of print] PubMed PMID: 29864689.

6: Kaur G, Silakari O. Benzimidazole scaffold based hybrid molecules for various inflammatory targets: Synthesis and evaluation. Bioorg Chem. 2018 May 18;80:24-35. doi: 10.1016/j.bioorg.2018.05.014. [Epub ahead of print] PubMed PMID: 29864685.

7: Fekedulegn D, Innes K, Andrew ME, Tinney-Zara C, Charles LE, Allison P, Violanti JM, Knox SS. Sleep quality and the cortisol awakening response (CAR) among law enforcement officers: The moderating role of leisure time physical activity. Psychoneuroendocrinology. 2018 May 28;95:158-169. doi: 10.1016/j.psyneuen.2018.05.034. [Epub ahead of print] PubMed PMID: 29864672.

8: Yang WK, Chiang LF, Tan SW, Chen PJ. Environmentally relevant concentrations of di(2-ethylhexyl)phthalate exposure alter larval growth and locomotion in medaka fish via multiple pathways. Sci Total Environ. 2018 Jun 1;640-641:512-522. doi: 10.1016/j.scitotenv.2018.05.312. [Epub ahead of print] PubMed PMID: 29864665.

9: How CM, Li SW, Liao VH. Chronic exposure to triadimenol at environmentally relevant concentration adversely affects aging biomarkers in Caenorhabditis elegans associated with insulin/IGF-1 signaling pathway. Sci Total Environ. 2018 Jun 1;640-641:485-492. doi: 10.1016/j.scitotenv.2018.05.314. [Epub ahead of print] PubMed PMID: 29864662.

10: Jiang P, Liu G, Cui W, Cai Y. Geochemical modeling of mercury speciation in surface water and implications on mercury cycling in the everglades wetland. Sci Total Environ. 2018 Jun 1;640-641:454-465. doi: 10.1016/j.scitotenv.2018.05.216. [Epub ahead of print] PubMed PMID: 29864659.

11: Thapa R, Gupta S, Gupta A, Reddy DV, Kaur H. Geochemical and geostatistical appraisal of fluoride contamination: An insight into the Quaternary aquifer. Sci Total Environ. 2018 Jun 1;640-641:406-418. doi: 10.1016/j.scitotenv.2018.05.360. [Epub ahead of print] PubMed PMID: 29864657.

12: Carriero G, Neri L, Famulari D, Di Lonardo S, Piscitelli D, Manco A, Esposito A, Chirico A, Facini O, Finardi S, Tinarelli G, Prandi R, Zaldei A, Vagnoli C, Toscano P, Magliulo V, Ciccioli P, Baraldi R. Composition and emission of VOC from biogas produced by illegally managed waste landfills in Giugliano (Campania, Italy) and potential impact on the local population. Sci Total Environ. 2018 Jun 1;640-641:377-386. doi: 10.1016/j.scitotenv.2018.05.318. [Epub ahead of print] PubMed PMID: 29864655.

13: Paul BK, Ghosh N, Mukherjee S. Association and sequestered dissociation of an anticancer drug from liposome membrane: Role of hydrophobic hydration. Colloids Surf B Biointerfaces. 2018 May 29;170:36-44. doi: 10.1016/j.colsurfb.2018.05.064. [Epub ahead of print] PubMed PMID: 29864652.

14: Yan W, Guo Y, Xiao Y, Wang S, Ding R, Jiang J, Gang H, Wang H, Yang J, Zhao F. The changes of bacterial communities and antibiotic resistance genes in microbial fuel cells during long-term oxytetracycline processing. Water Res. 2018 May 28;142:105-114. doi: 10.1016/j.watres.2018.05.047. [Epub ahead of print] PubMed PMID: 29864646.

15: Gu P, Zhang G, Deng Z, Tang Z, Zhang H, Khusbu FY, Wu K, Chen M, Ma C. A novel label-free colorimetric detection of l-histidine using Cu(2+)-modulated G-quadruplex-based DNAzymes. Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 28;203:195-200. doi: 10.1016/j.saa.2018.05.084. [Epub ahead of print] PubMed PMID: 29864643.

16: Nagaradona S, Dhanakotti RB. Spectral, nonlinear optical and optical limiting properties of l-phenylalanine l-phenylalaninium formate single crystal. Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 28;203:147-157. doi: 10.1016/j.saa.2018.05.095. [Epub ahead of print] PubMed PMID: 29864638.

17: Acosta C, Barat JM, Martínez-Máñez R, Sancenón F, Llopis S, González N, Genovés S, Ramón D, Martorell P. Toxicological assessment of mesoporous silica particles in the nematode Caenorhabditis elegans. Environ Res. 2018 Jun 1;166:61-70. doi: 10.1016/j.envres.2018.05.018. [Epub ahead of print] PubMed PMID: 29864634.

18: Montagna MT, De Giglio O, Napoli C, Diella G, Rutigliano S, Agodi A, Auxilia F, Baldovin T, Bisetto F, Arnoldo L, Brusaferro S, Busetti M, Calagreti G, Casini B, Cristina ML, Di Luzio R, Fiorio M, Formoso M, Liguori G, Martini E, Molino A, Mondello P, Mura I, Novati R, Orsi GB, Patroni A, Poli A, Privitera G, Ripabelli G, Rocchetti A, Rose F, Sarti M, Savini S, Silvestri A, Sodano L, Spagnolo AM, Tardivo S, Teti V, Torregrossa MV, Torri E, Veronesi L, Zarrilli R, Pacifico C, Goglio A, Moro M, Pasquarella C. Control and prevention measures for legionellosis in hospitals: A cross-sectional survey in Italy. Environ Res. 2018 Jun 1;166:55-60. doi: 10.1016/j.envres.2018.05.030. [Epub ahead of print] PubMed PMID: 29864633.

19: Fraga BM, Terrero D, Cabrera I, Reina M. Studies on the sesquiterpene lactones from Laurus novocanariensis lead to the clarification of the structures of 1-epi-tatridin B and its epimer tatridin B. Phytochemistry. 2018 Jun 1;153:48-52. doi: 10.1016/j.phytochem.2018.05.014. [Epub ahead of print] PubMed PMID: 29864627.

20: Yao GD, Ge MY, Li DQ, Chen L, Hayashi T, Tashiro SI, Onodera S, Guo C, Song SJ, Ikejima T. L-A03, a dihydroartemisinin derivative, promotes apoptotic cell death of human breast cancer MCF-7 cells by targeting c-Jun N-terminal kinase. Biomed Pharmacother. 2018 Jun 1;105:320-325. doi: 10.1016/j.biopha.2018.05.093. [Epub ahead of print] PubMed PMID: 29864620.