WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596697
CAS#: 182251-68-9
Description: L-770644 dihydrochloride is a potent and selective human beta3 adrenergic receptor agonist.
MedKoo Cat#: 596697
Name: L-770644 dihydrochloride
CAS#: 182251-68-9
Chemical Formula: C30H39Cl2N7O4S
Exact Mass:
Molecular Weight: 664.64
Elemental Analysis: C, 54.21; H, 5.91; Cl, 10.67; N, 14.75; O, 9.63; S, 4.82
Synonym: L-770644 dihydrochloride;
IUPAC/Chemical Name: (R)-4-(4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)-N-(4-(2-((2-hydroxy-2-(pyridin-3-yl)ethyl)amino)ethyl)phenyl)benzenesulfonamide dihydrochloride
InChi Key: XUVXLYDLMIEXER-UJXPALLWSA-N
InChi Code: InChI=1S/C30H37N7O4S.2ClH/c38-29(25-8-3-18-31-21-25)22-32-19-17-24-9-11-26(12-10-24)33-42(40,41)28-15-13-27(14-16-28)37-30(39)36(34-35-37)20-4-7-23-5-1-2-6-23;;/h3,8-16,18,21,23,29,32-33,38H,1-2,4-7,17,19-20,22H2;2*1H/t29-;;/m0../s1
SMILES Code: O=S(C1=CC=C(N2N=NN(CCCC3CCCC3)C2=O)C=C1)(NC4=CC=C(CCNC[C@H](O)C5=CC=CN=C5)C=C4)=O.[H]Cl.[H]Cl
1: Colwell LF Jr, Tamvakopoulos CS, Wang PR, Pivnichny JV, Shih TL. Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography--atmospheric pressure ionization tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25;772(1):89-98. PubMed PMID: 12016019.
2: Shih TL, Candelore MR, Cascieri MA, Chiu SH, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Miller RR, Stearns RA, Strader CD, Tota L, Wyvratt MJ, Fisher MH, Weber AE. L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability. Bioorg Med Chem Lett. 1999 May 3;9(9):1251-4. PubMed PMID: 10340609.