WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596697
CAS#: 182251-68-9
Description: L-770644 dihydrochloride is a potent and selective human beta3 adrenergic receptor agonist.
MedKoo Cat#: 596697
Name: L-770644 dihydrochloride
CAS#: 182251-68-9
Chemical Formula: C30H39Cl2N7O4S
Exact Mass:
Molecular Weight: 664.64
Elemental Analysis: C, 54.21; H, 5.91; Cl, 10.67; N, 14.75; O, 9.63; S, 4.82
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: L-770644 dihydrochloride;
IUPAC/Chemical Name: (R)-4-(4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)-N-(4-(2-((2-hydroxy-2-(pyridin-3-yl)ethyl)amino)ethyl)phenyl)benzenesulfonamide dihydrochloride
InChi Key: XUVXLYDLMIEXER-UJXPALLWSA-N
InChi Code: InChI=1S/C30H37N7O4S.2ClH/c38-29(25-8-3-18-31-21-25)22-32-19-17-24-9-11-26(12-10-24)33-42(40,41)28-15-13-27(14-16-28)37-30(39)36(34-35-37)20-4-7-23-5-1-2-6-23;;/h3,8-16,18,21,23,29,32-33,38H,1-2,4-7,17,19-20,22H2;2*1H/t29-;;/m0../s1
SMILES Code: O=S(C1=CC=C(N2N=NN(CCCC3CCCC3)C2=O)C=C1)(NC4=CC=C(CCNC[C@H](O)C5=CC=CN=C5)C=C4)=O.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 664.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Colwell LF Jr, Tamvakopoulos CS, Wang PR, Pivnichny JV, Shih TL. Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography--atmospheric pressure ionization tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25;772(1):89-98. PubMed PMID: 12016019.
2: Shih TL, Candelore MR, Cascieri MA, Chiu SH, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Miller RR, Stearns RA, Strader CD, Tota L, Wyvratt MJ, Fisher MH, Weber AE. L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability. Bioorg Med Chem Lett. 1999 May 3;9(9):1251-4. PubMed PMID: 10340609.
