L-770644

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596694

CAS#: 173901-95-6

Description: L-770644 is a B3 adrenergic receptor agonist.


Price and Availability

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L-770644 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596694
Name: L-770644
CAS#: 173901-95-6
Chemical Formula: C30H37N7O4S
Exact Mass: 591.2628
Molecular Weight: 591.73
Elemental Analysis: C, 60.89; H, 6.30; N, 16.57; O, 10.82; S, 5.42


Synonym: L-770644; L 770644; L770644;

IUPAC/Chemical Name: (R)-4-(4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)-N-(4-(2-((2-hydroxy-2-(pyridin-3-yl)ethyl)amino)ethyl)phenyl)benzenesulfonamide

InChi Key: GCRTUWDFTYDUFB-LJAQVGFWSA-N

InChi Code: InChI=1S/C30H37N7O4S/c38-29(25-8-3-18-31-21-25)22-32-19-17-24-9-11-26(12-10-24)33-42(40,41)28-15-13-27(14-16-28)37-30(39)36(34-35-37)20-4-7-23-5-1-2-6-23/h3,8-16,18,21,23,29,32-33,38H,1-2,4-7,17,19-20,22H2/t29-/m0/s1

SMILES Code: O=S(C1=CC=C(N2N=NN(CCCC3CCCC3)C2=O)C=C1)(NC4=CC=C(CCNC[C@H](O)C5=CC=CN=C5)C=C4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Colwell LF Jr, Tamvakopoulos CS, Wang PR, Pivnichny JV, Shih TL. Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography--atmospheric pressure ionization tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25;772(1):89-98. PubMed PMID: 12016019.

2: Shih TL, Candelore MR, Cascieri MA, Chiu SH, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Miller RR, Stearns RA, Strader CD, Tota L, Wyvratt MJ, Fisher MH, Weber AE. L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability. Bioorg Med Chem Lett. 1999 May 3;9(9):1251-4. PubMed PMID: 10340609.