L 738167

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596690

CAS#: 163212-43-9

Description: L 738167 is a potent and long-acting fibrinogen receptor antagonist.


Price and Availability

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L 738167 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596690
Name: L 738167
CAS#: 163212-43-9
Chemical Formula: C25H34N6O6S
Exact Mass: 546.2261
Molecular Weight: 546.64
Elemental Analysis: C, 54.93; H, 6.27; N, 15.37; O, 17.56; S, 5.86


Synonym: L 738167; L-738167; L738167;

IUPAC/Chemical Name: (S)-2-((4-methylphenyl)sulfonamido)-3-(4-oxo-5-(2-(piperidin-4-yl)ethyl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamido)propanoic acid

InChi Key: YLFFZEQHDMFOEC-NRFANRHFSA-N

InChi Code: InChI=1S/C25H34N6O6S/c1-17-3-5-19(6-4-17)38(36,37)29-21(25(34)35)16-27-23(32)20-15-22-24(33)30(12-2-13-31(22)28-20)14-9-18-7-10-26-11-8-18/h3-6,15,18,21,26,29H,2,7-14,16H2,1H3,(H,27,32)(H,34,35)/t21-/m0/s1

SMILES Code: O=C(O)[C@H](CNC(C1=NN2C(C(N(CCC3CCNCC3)CCC2)=O)=C1)=O)NS(=O)(C4=CC=C(C)C=C4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bednar B, Cook JJ, Holahan MA, Cunningham ME, Jumes PA, Bednar RA, Hartman GD, Gould RJ. Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa. Blood. 1999 Jul 15;94(2):587-99. PubMed PMID: 10397726.

2: Bray ML, Jahansouz H, Kaufman MJ. Selection of optimal hydrate/solvate forms of a fibrinogen receptor antagonist for solid dosage development. Pharm Dev Technol. 1999 Jan;4(1):81-7. PubMed PMID: 10027216.

3: Bednar RA, Gaul SL, Hamill TG, Egbertson MS, Shafer JA, Hartman GD, Gould RJ, Bednar B. Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets. J Pharmacol Exp Ther. 1998 Jun;285(3):1317-26. PubMed PMID: 9618439.

4: Cook JJ, Glass JD, Sitko GR, Holahan MA, Stupienski RF 3rd, Wallace AA, Stump GL, Hand EL, Askew BC, Hartman GD, Gould RJ, Lynch JJ Jr. Nonpeptide glycoprotein IIb/IIIa inhibitors: 14: oral antithrombotic efficacy of L-738,167 in a conscious canine model of coronary artery electrolytic injury. Circulation. 1997 Aug 5;96(3):949-58. PubMed PMID: 9264506.

5: Askew BC, Bednar RA, Bednar B, Claremon DA, Cook JJ, McIntyre CJ, Hunt CA, Gould RJ, Lynch RJ, Lynch JJ Jr, Gaul SL, Stranieri MT, Sitko GR, Holahan MA, Glass JD, Hamill T, Gorham LM, Prueksaritanont T, Baldwin JJ, Hartman GD. Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists. J Med Chem. 1997 Jun 6;40(12):1779-88. PubMed PMID: 9191954.

6: Cook JJ, Sitko GR, Holahan MA, Stranieri MT, Glass JD, Askew BC, McIntyre CJ, Claremon DA, Baldwin JJ, Hartman GD, Gould RJ, Lynch JJ Jr. Nonpeptide glycoprotein IIb/IIIa inhibitors. 15. Antithrombotic efficacy of L-738,167, a long-acting GPIIb/IIIa antagonist, correlates with inhibition of adenosine diphosphate-induced platelet aggregation but not with bleeding time prolongation. J Pharmacol Exp Ther. 1997 May;281(2):677-89. PubMed PMID: 9152373.

7: Prueksaritanont T, Gorham LM, Naue JA, Hamill TG, Askew BC, Vyas KP. Disposition of L-738,167, a potent and long-acting fibrinogen receptor antagonist, in dogs. Dose-dependent pharmacokinetics. Drug Metab Dispos. 1997 Mar;25(3):355-61. PubMed PMID: 9172954.