L 738372

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MedKoo CAT#: 596687

CAS#: 159565-60-3

Description: L 738372 is a quinazolinone; a non-nucleoside inhibitor of HIV-1 reverse transcriptase.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-07. Prices are subject to change without notice.

L 738372 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596687
Name: L 738372
CAS#: 159565-60-3
Chemical Formula: C18H15N3O
Exact Mass: 289.1215
Molecular Weight: 289.33
Elemental Analysis: C, 74.72; H, 5.23; N, 14.52; O, 5.53

Synonym: L 738372; L-738372; L738372; L-738,372; L 738,372; L738,372;

IUPAC/Chemical Name: (S)-4-cyclopropyl-4-(pyridin-2-ylethynyl)-3,4-dihydroquinazolin-2(1H)-one


InChi Code: InChI=1S/C18H15N3O/c22-17-20-16-7-2-1-6-15(16)18(21-17,13-8-9-13)11-10-14-5-3-4-12-19-14/h1-7,12-13H,8-9H2,(H2,20,21,22)/t18-/m1/s1

SMILES Code: O=C1NC2=C(C=CC=C2)[C@@](C#CC3=NC=CC=C3)(C4CC4)N1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Wang T, Grinberg N, Bicker G, Tway P, Thompson K. High-performance liquid chromatographic separation of an HIV-1 reverse transcriptase inhibitor and its enantiomer. J Chromatogr A. 1996 Jul 12;738(2):290-4. PubMed PMID: 8696508.

2: Prueksaritanont T, Balani SK, Dwyer LM, Ellis JD, Kauffman LR, Varga SL, Pitzenberger SM, Theoharides AD. Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human. Drug Metab Dispos. 1995 Jul;23(7):688-95. PubMed PMID: 7587955.

3: Carroll SS, Stahlhut M, Geib J, Olsen DB. Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs. J Biol Chem. 1994 Dec 23;269(51):32351-7. PubMed PMID: 7528214.