L 741742 (free base)

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MedKoo CAT#: 596683

CAS#: 156337-32-5

Description: L 741742 (free base) is a potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-04. Prices are subject to change without notice.

L 741742 (free base) is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596683
Name: L 741742 (free base)
CAS#: 156337-32-5
Chemical Formula: C23H25ClN2O
Exact Mass: 380.1655
Molecular Weight: 380.91
Elemental Analysis: C, 72.52; H, 6.62; Cl, 9.31; N, 7.35; O, 4.20

Related CAS #: 874882-93-6 (HCl)  

Synonym: L 741742 (free base); L 741742; L-741742; L741742; L-741,742; L 741,742; L741,742;

IUPAC/Chemical Name: 5-(4-chlorophenyl)-4-methyl-3-(1-phenethylpiperidin-4-yl)isoxazole


InChi Code: InChI=1S/C23H25ClN2O/c1-17-22(25-27-23(17)20-7-9-21(24)10-8-20)19-12-15-26(16-13-19)14-11-18-5-3-2-4-6-18/h2-10,19H,11-16H2,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Root DH, Hoffman AF, Good CH, Zhang S, Gigante E, Lupica CR, Morales M. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015 Feb 25;35(8):3460-9. doi: 10.1523/JNEUROSCI.4525-13.2015. PubMed PMID: 25716845; PubMed Central PMCID: PMC4339355.

2: Bastianetto S, Danik M, Mennicken F, Williams S, Quirion R. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC Neurosci. 2006 Mar 30;7:28. PubMed PMID: 16573831; PubMed Central PMCID: PMC1448194.

3: Cao BJ, Rodgers RJ. Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze. Eur J Pharmacol. 1997 Sep 24;335(2-3):117-25. PubMed PMID: 9369363.

4: Rowley M, Broughton HB, Collins I, Baker R, Emms F, Marwood R, Patel S, Patel S, Ragan CI, Freedman SB, Leeson PD. 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J Med Chem. 1996 May 10;39(10):1943-5. PubMed PMID: 8642551.