L 705589

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MedKoo CAT#: 596682

CAS#: 150220-81-8

Description: L 705589 is a water-soluble semisynthetic pneumocandin Bo derivative.

Price and Availability

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Pricing updated 2020-04-01. Prices are subject to change without notice.

L 705589 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596682
Name: L 705589
CAS#: 150220-81-8
Chemical Formula: C52H85N9O17
Exact Mass: 1107.6063
Molecular Weight: 1108.29
Elemental Analysis: C, 56.35; H, 7.73; N, 11.37; O, 24.54

Synonym: L 705589; L-705589; L705589;

IUPAC/Chemical Name: N-((2R,6S,9S,11R,12R,14aS,16R,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-12-(2-aminoethoxy)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,16-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide


InChi Code: InChI=1S/C52H85N9O17/c1-5-27(2)20-28(3)12-10-8-6-7-9-11-13-40(69)55-34-23-38(67)50(78-19-18-53)59-48(74)36-22-33(65)26-61(36)52(77)42(37(66)24-39(54)68)57-49(75)43(45(71)44(70)30-14-16-31(63)17-15-30)58-47(73)35-21-32(64)25-60(35)51(76)41(29(4)62)56-46(34)72/h14-17,27-29,32-38,41-45,50,62-67,70-71H,5-13,18-26,53H2,1-4H3,(H2,54,68)(H,55,69)(H,56,72)(H,57,75)(H,58,73)(H,59,74)/t27?,28?,29-,32-,33-,34+,35+,36+,37-,38-,41+,42+,43+,44+,45+,50-/m1/s1

SMILES Code: CCC(CC(CCCCCCCCC(N[C@H]1C[C@@H](O)[C@@H](OCCN)NC([C@@H]2C[C@@H](O)CN2C([C@H]([C@H](O)CC(N)=O)NC([C@H]([C@H](O)[C@@H](O)c3ccc(O)cc3)NC([C@@H]4C[C@@H](O)CN4C([C@H]([C@H](O)C)NC1=O)=O)=O)=O)=O)=O)=O)C)C

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Schmatz DM, Powles MA, McFadden D, Nollstadt K, Bouffard FA, Dropinski JF, Liberator P, Andersen J. New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat. Antimicrob Agents Chemother. 1995 Jun;39(6):1320-3. PubMed PMID: 7574523; PubMed Central PMCID: PMC162734.

2: Abruzzo GK, Flattery AM, Gill CJ, Kong L, Smith JG, Krupa D, Pikounis VB, Kropp H, Bartizal K. Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob Agents Chemother. 1995 May;39(5):1077-81. PubMed PMID: 7625792; PubMed Central PMCID: PMC162686.

3: Bartizal K, Scott T, Abruzzo GK, Gill CJ, Pacholok C, Lynch L, Kropp H. In vitro evaluation of the pneumocandin antifungal agent L-733560, a new water-soluble hybrid of L-705589 and L-731373. Antimicrob Agents Chemother. 1995 May;39(5):1070-6. PubMed PMID: 7625791; PubMed Central PMCID: PMC162685.