L 731734

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MedKoo CAT#: 596681

CAS#: 149786-89-0

Description: L 731734 is an inhibitor of farnesyltransferase; a prodrug of L 731735.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-12. Prices are subject to change without notice.

L 731734 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596681
Name: L 731734
CAS#: 149786-89-0
Chemical Formula: C19H38N4O3S
Exact Mass: 402.2665
Molecular Weight: 402.59
Elemental Analysis: C, 56.68; H, 9.51; N, 13.92; O, 11.92; S, 7.96

Synonym: L 731734; L-731734; L731734; L-731,734; L731,734; L 731,734;

IUPAC/Chemical Name: (2S,3S)-2-((2-((2-amino-3-mercaptopropyl)amino)-3-methylpentyl)amino)-3-methyl-N-(2-oxotetrahydrofuran-3-yl)pentanamide


InChi Code: InChI=1S/C19H38N4O3S/c1-5-12(3)16(21-9-14(20)11-27)10-22-17(13(4)6-2)18(24)23-15-7-8-26-19(15)25/h12-17,21-22,27H,5-11,20H2,1-4H3,(H,23,24)/t12?,13-,14?,15?,16?,17-/m0/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Kohl NE, Wilson FR, Thomas TJ, Bock RL, Mosser SD, Oliff A, Gibbs JB. Inhibition of Ras function in vitro and in vivo using inhibitors of farnesyl-protein transferase. Methods Enzymol. 1995;255:378-86. PubMed PMID: 8524123.

2: Graham SL, deSolms SJ, Giuliani EA, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Breslin MJ, Deana AA, et al. Pseudopeptide inhibitors of Ras farnesyl-protein transferase. J Med Chem. 1994 Mar 18;37(6):725-32. PubMed PMID: 8145221.

3: Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompliano DL, Graham SL, Smith RL, Scolnick EM, Oliff A, Gibbs JB. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science. 1993 Jun 25;260(5116):1934-7. PubMed PMID: 8316833.