L 731735

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596680

CAS#: 149756-20-7

Description: L 731735 is an inhibitor of farnesyltransferase.


Price and Availability

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L 731735 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596680
Name: L 731735
CAS#: 149756-20-7
Chemical Formula: C19H40N4O4S
Exact Mass: 420.277
Molecular Weight: 420.61
Elemental Analysis: C, 54.26; H, 9.59; N, 13.32; O, 15.21; S, 7.62


Synonym: L 731735; L-731735; L731735; L-731,735; L 731,735; L731,735;

IUPAC/Chemical Name: (2-((2-amino-3-mercaptopropyl)amino)-3-methylpentyl)-L-alloisoleucyl-L-homoserine

InChi Key: LMTIEVNRUFAFPM-AYMFQPPXSA-N

InChi Code: InChI=1S/C19H40N4O4S/c1-5-12(3)16(21-9-14(20)11-28)10-22-17(13(4)6-2)18(25)23-15(7-8-24)19(26)27/h12-17,21-22,24,28H,5-11,20H2,1-4H3,(H,23,25)(H,26,27)/t12?,13-,14?,15+,16?,17+/m1/s1

SMILES Code: OCC[C@@H](C(O)=O)NC([C@H]([C@H](C)CC)NCC(NCC(N)CS)C(C)CC)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompliano DL, Graham SL, Smith RL, Scolnick EM, Oliff A, Gibbs JB. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science. 1993 Jun 25;260(5116):1934-7. PubMed PMID: 8316833.