L-732531

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596679

CAS#: 148365-48-4

Description: L-732531 is a tacrolimus-related immunosuppressant with reduced toxicity.


Price and Availability

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L-732531 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596679
Name: L-732531
CAS#: 148365-48-4
Chemical Formula: C53H78N2O13
Exact Mass: 950.5504
Molecular Weight: 951.2
Elemental Analysis: C, 66.92; H, 8.27; N, 2.95; O, 21.87


Synonym: L-732531; L 732531; L732531;

IUPAC/Chemical Name: (1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-{[1-(2-hydroxyethyl)-1H-indol-5-yl]oxy}-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone

InChi Key: UTOJCEZANIVKJJ-IUQQQLKSSA-N

InChi Code: InChI=1S/C53H78N2O13/c1-10-37-24-31(2)23-32(3)25-46(64-8)49-47(65-9)27-34(5)53(62,68-49)50(59)51(60)55-19-12-11-13-41(55)52(61)67-48(35(6)42(57)30-43(37)58)33(4)26-36-14-17-44(45(28-36)63-7)66-39-15-16-40-38(29-39)18-20-54(40)21-22-56/h15-16,18,20,24,26,29,32,34-37,41-42,44-49,56-57,62H,10-14,17,19,21-23,25,27-28,30H2,1-9H3/b31-24+,33-26+/t32-,34+,35+,36-,37+,41-,42-,44+,45+,46-,47-,48+,49+,53+/m0/s1

SMILES Code: CC[C@@H]1/C=C(C[C@@H](C[C@@H]([C@H]2O[C@]([C@@H](C[C@@H]2OC)C)(C(C(N3CCCC[C@H]3C(O[C@H](/C(C)=C/[C@@H]4CC[C@H]([C@H](OC)C4)Oc5cc6ccn(CCO)c6cc5)[C@@H]([C@H](CC1=O)O)C)=O)=O)=O)O)OC)C)\C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M. Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2322-7. Epub 2003 Feb 26. PubMed PMID: 12606707; PubMed Central PMCID: PMC151339.

2: Karanam BV, Miller RR, Colletti A, Montgomery T, Carey KD, Hawkins T, Tang YS, Lavin M, Stearns RA, Chiu SH, Vincent SH. Disposition of L-732,531, a potent immunosuppressant, in rats and baboons. Drug Metab Dispos. 1998 Oct;26(10):949-57. PubMed PMID: 9763399.

3: Salowe SP, Hermes JD. Competitive and slow-binding inhibition of calcineurin by drug x immunophilin complexes. Arch Biochem Biophys. 1998 Jul 15;355(2):165-74. PubMed PMID: 9675023.

4: Dumont FJ, Koprak S, Staruch MJ, Talento A, Koo G, DaSilva C, Sinclair PJ, Wong F, Woods J, Barker J, Pivnichny J, Singer I, Sigal NH, Williamson AR, Parsons WH, Wyvratt M. A tacrolimus-related immunosuppressant with reduced toxicity. Transplantation. 1998 Jan 15;65(1):18-26. PubMed PMID: 9448138.

5: Peterson LB, Cryan JG, Rosa R, Martin MM, Wilusz MB, Sinclair PJ, Wong F, Parsons JN, O'Keefe SJ, Parsons WH, Wyvratt M, Sigal NH, Williamson AR, Wiederrecht GJ. A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus. Transplantation. 1998 Jan 15;65(1):10-8. PubMed PMID: 9448137.