L 708286

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596669

CAS#: 119720-81-9

Description: L 708286 is a peptide-based phenethylcarbamoyldifluoromethylene compound; slow-binding inhibitor of human leucocyte elastase (HLE).

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-29. Prices are subject to change without notice.

L 708286 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596669
Name: L 708286
CAS#: 119720-81-9
Chemical Formula: C25H34F2N4O5
Exact Mass: 508.2497
Molecular Weight: 508.56
Elemental Analysis: C, 59.04; H, 6.74; F, 7.47; N, 11.02; O, 15.73

Synonym: L 708286; L-708286; L708286; DFKi;

IUPAC/Chemical Name: (S)-1-(acetyl-L-alanyl)-N-((S)-5,5-difluoro-2-methyl-4,6-dioxo-6-(phenethylamino)hexan-3-yl)pyrrolidine-2-carboxamide


InChi Code: InChI=1S/C25H34F2N4O5/c1-15(2)20(21(33)25(26,27)24(36)28-13-12-18-9-6-5-7-10-18)30-22(34)19-11-8-14-31(19)23(35)16(3)29-17(4)32/h5-7,9-10,15-16,19-20H,8,11-14H2,1-4H3,(H,28,36)(H,29,32)(H,30,34)/t16-,19-,20-/m0/s1

SMILES Code: O=C(N[C@@H](C(C)C)C(C(F)(F)C(NCCC1=CC=CC=C1)=O)=O)[C@H]2N(C([C@H](C)NC(C)=O)=O)CCC2

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Zhang L, Song L, Terracina G, Liu Y, Pramanik B, Parker E. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides. Biochemistry. 2001 Apr 24;40(16):5049-55. PubMed PMID: 11305921.

2: Masek BB, Merchant A, Matthew JB. Molecular skins: a new concept for quantitative shape matching of a protein with its small molecule mimics. Proteins. 1993 Oct;17(2):193-202. PubMed PMID: 8265566.

3: Knight WB, Swiderek KM, Sakuma T, Calaycay J, Shively JE, Lee TD, Covey TR, Shushan B, Green BG, Chabin R, et al. Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex. Biochemistry. 1993 Mar 2;32(8):2031-5. PubMed PMID: 8095408.