L 699333

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MedKoo CAT#: 596664

CAS#: 155238-60-1

Description: L 699333 is a 5-lipoxygenase inhibitor.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-29. Prices are subject to change without notice.

L 699333 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596664
Name: L 699333
CAS#: 155238-60-1
Chemical Formula: C36H35ClN2O4S
Exact Mass: 626.2006
Molecular Weight: 627.19
Elemental Analysis: C, 68.94; H, 5.63; Cl, 5.65; N, 4.47; O, 10.20; S, 5.11


Synonym: L 699333; L-699333; L699333; L-699,333; L 699,333; L699,333;

IUPAC/Chemical Name: (R)-2-(2-((S)-1-(4-chlorobenzyl)-4-methyl-6-((5-phenylpyridin-2-yl)methoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl)ethoxy)butanoic acid

InChi Key: JCBSPQXPBDDSEZ-JPQMRUPTSA-N

InChi Code: InChI=1S/C36H35ClN2O4S/c1-3-32(36(40)41)42-18-17-31-35-34-29(19-23(2)44-35)33(16-15-30(34)39(31)21-24-9-12-27(37)13-10-24)43-22-28-14-11-26(20-38-28)25-7-5-4-6-8-25/h4-16,20,23,32H,3,17-19,21-22H2,1-2H3,(H,40,41)/t23-,32+/m0/s1

SMILES Code: CC[C@@H](OCCC(N1CC2=CC=C(Cl)C=C2)=C3C4=C1C=CC(OCC5=NC=C(C6=CC=CC=C6)C=C5)=C4C[C@H](C)S3)C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Gupta N, Greeser MJ, Ford-Hutchinson AW. A random rapid equilibrium mechanism for leukotriene C4 synthase. Adv Exp Med Biol. 1999;469:327-32. PubMed PMID: 10667349.

2: Gupta N, Gresser MJ, Ford-Hutchinson AW. Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase. Biochim Biophys Acta. 1998 Mar 30;1391(2):157-68. PubMed PMID: 9554994.

3: Negro JM, Miralles JC, Ortiz JL, Funes E, García A. Biosynthesis inhibitors for leukotrienes in bronchial asthma. Allergol Immunopathol (Madr). 1997 Jul-Aug;25(4):209-16. Review. PubMed PMID: 9269512.

4: Hutchinson JH, Riendeau D, Brideau C, Chan C, Falgueyret JP, Guay J, Jones TR, Lépine C, Macdonald D, McFarlane CS, et al. Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. J Med Chem. 1994 Apr 15;37(8):1153-64. PubMed PMID: 8164257.