L 696418

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MedKoo CAT#: 596663

CAS#: 154096-58-9

Description: L 696418 inhibits stromelysin.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-29. Prices are subject to change without notice.

L 696418 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596663
Name: L 696418
CAS#: 154096-58-9
Chemical Formula: C25H33N3O4
Exact Mass: 439.2471
Molecular Weight: 439.55
Elemental Analysis: C, 68.31; H, 7.57; N, 9.56; O, 14.56


Synonym: L 696418; L-696418; L696418; L-696,418; L 696,418; L696,418;

IUPAC/Chemical Name: N-((2S)-1-(2-aminobutanamido)-4-methyl-1-oxo-4-phenylpentan-2-yl)-N-phenyl-L-alanine

InChi Key: IEDGXRXVOXOMIW-ZPWCZAOQSA-N

InChi Code: InChI=1S/C25H33N3O4/c1-5-20(26)22(29)27-23(30)21(16-25(3,4)18-12-8-6-9-13-18)28(17(2)24(31)32)19-14-10-7-11-15-19/h6-15,17,20-21H,5,16,26H2,1-4H3,(H,31,32)(H,27,29,30)/t17-,20?,21-/m0/s1

SMILES Code: CC(C)(C1=CC=CC=C1)C[C@@H](C(NC(C(N)CC)=O)=O)N([C@H](C(O)=O)C)C2=CC=CC=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Esser CK, Bugianesi RL, Caldwell CG, Chapman KT, Durette PL, Girotra NN, Kopka IE, Lanza TJ, Levorse DA, MacCoss M, Owens KA, Ponpipom MM, Simeone JP, Harrison RK, Niedzwiecki L, Becker JW, Marcy AI, Axel MG, Christen AJ, McDonnell J, Moore VL, Olszewski JM, Saphos C, Visco DM, Hagmann WK, et al. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. J Med Chem. 1997 Mar 14;40(6):1026-40. PubMed PMID: 9083493.

2: Bonassar LJ, Stinn JL, Paguio CG, Frank EH, Moore VL, Lark MW, Sandy JD, Hollander AP, Poole AR, Grodzinsky AJ. Activation and inhibition of endogenous matrix metalloproteinases in articular cartilage: effects on composition and biophysical properties. Arch Biochem Biophys. 1996 Sep 15;333(2):359-67. PubMed PMID: 8809074.

3: Garcia AM, Frank EH, Grimshaw PE, Grodzinsky AJ. Contributions of fluid convection and electrical migration to transport in cartilage: relevance to loading. Arch Biochem Biophys. 1996 Sep 15;333(2):317-25. PubMed PMID: 8809069.

4: Bonassar LJ, Jeffries KA, Frank EH, Moore VL, Lark MW, Bayne EK, McDonnell J, Olszewski J, Hagmann W, Chapman K, et al. In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor. Arthritis Rheum. 1995 Nov;38(11):1678-86. PubMed PMID: 7488290.

5: Chapman KT, Kopka IE, Durette PL, Esser CK, Lanza TJ, Izquierdo-Martin M, Niedzwiecki L, Chang B, Harrison RK, Kuo DW, et al. Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides. J Med Chem. 1993 Dec 24;36(26):4293-301. PubMed PMID: 8277511.