L 691816

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MedKoo CAT#: 596662

CAS#: 150461-07-7

Description: L 691816 is a potent inhibitor of the 5-LO reaction both in vitro and in a range of in vivo models.


Price and Availability

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Pricing updated 2020-04-01. Prices are subject to change without notice.

L 691816 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596662
Name: L 691816
CAS#: 150461-07-7
Chemical Formula: C36H35ClN6OS
Exact Mass: 634.2282
Molecular Weight: 635.22
Elemental Analysis: C, 68.07; H, 5.55; Cl, 5.58; N, 13.23; O, 2.52; S, 5.05


Synonym: L 691816; L-691816; L691816; L-691,816; L 691,816; L691,816;

IUPAC/Chemical Name: 1-(4-chlorobenzyl)-2-(2,2-dimethyl-3-(1H-tetrazol-5-yl)propyl)-4-methyl-6-((5-phenylpyridin-2-yl)methoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indole

InChi Key: ZXTQNTHPGKKAHX-UHFFFAOYSA-N

InChi Code: InChI=1S/C36H35ClN6OS/c1-23-17-29-32(44-22-28-14-11-26(20-38-28)25-7-5-4-6-8-25)16-15-30-34(29)35(45-23)31(18-36(2,3)19-33-39-41-42-40-33)43(30)21-24-9-12-27(37)13-10-24/h4-16,20,23H,17-19,21-22H2,1-3H3,(H,39,40,41,42)

SMILES Code: CC(CC(N1CC2=CC=C(Cl)C=C2)=C3C4=C1C=CC(OCC5=NC=C(C6=CC=CC=C6)C=C5)=C4CC(C)S3)(C)CC7=NN=NN7


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Hutchinson JH, Riendeau D, Brideau C, Chan C, Delorme D, Denis D, Falgueyret JP, Fortin R, Guay J, Hamel P, et al. Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. J Med Chem. 1993 Sep 17;36(19):2771-87. PubMed PMID: 8410991.