L 694746

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MedKoo CAT#: 596657

CAS#: 139934-80-8

Description: L 694746 is a HIV-1 protease inhibitor.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-29. Prices are subject to change without notice.

L 694746 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596657
Name: L 694746
CAS#: 139934-80-8
Chemical Formula: C35H42N2O8
Exact Mass: 618.2941
Molecular Weight: 618.72
Elemental Analysis: C, 67.94; H, 6.84; N, 4.53; O, 20.69


Synonym: L 694746; L-694746; L694746; L-694,746; L 694,746; L694,746;

IUPAC/Chemical Name: 2-(4-((2S,4S,5S)-5-((tert-butoxycarbonyl)amino)-4-hydroxy-2-(((1R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)carbamoyl)-6-phenylhexyl)phenoxy)acetic acid

InChi Key: YDOBPQZYAZNHNJ-ACUYYOAISA-N

InChi Code: InChI=1S/C35H42N2O8/c1-35(2,3)45-34(43)36-28(18-22-9-5-4-6-10-22)29(38)20-25(17-23-13-15-26(16-14-23)44-21-31(40)41)33(42)37-32-27-12-8-7-11-24(27)19-30(32)39/h4-16,25,28-30,32,38-39H,17-21H2,1-3H3,(H,36,43)(H,37,42)(H,40,41)/t25-,28-,29-,30?,32+/m0/s1

SMILES Code: O=C(O)COC1=CC=C(C[C@H](C(N[C@H]2C(O)CC3=C2C=CC=C3)=O)C[C@H](O)[C@@H](NC(OC(C)(C)C)=O)CC4=CC=CC=C4)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Franchetti P, Perlini P, Abu Sheikha G, Cappellacci L, Grifantini M, Loi AG, De Montis A, Pani A, Marongiu ME, La Colla P. Potent and selective inhibitors of human immunodeficiency virus protease structurally related to L-694,746. Antivir Chem Chemother. 1998 Jul;9(4):303-9. PubMed PMID: 9875409.

2: Lingham RB, Arison BH, Colwell LF, Hsu A, Dezeny G, Thompson WJ, Garrity GM, Gagliardi MM, Hartner FW, Darke PL, et al. HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1456-61. PubMed PMID: 1764098.