L 693989

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MedKoo CAT#: 596655

CAS#: 138661-20-8

Description: L 693989 is a pneumocandin.

Price and Availability

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Pricing updated 2020-03-29. Prices are subject to change without notice.

L 693989 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596655
Name: L 693989
CAS#: 138661-20-8
Chemical Formula: C50H80N8NaO20P
Exact Mass: 1166.5124
Molecular Weight: 1167.18
Elemental Analysis: C, 51.45; H, 6.91; N, 9.60; Na, 1.97; O, 27.41; P, 2.65

Synonym: L 693989; L-693989; L693989; L-693,989; L 693,989; L693,989;

IUPAC/Chemical Name: sodium 4-((1S,2R)-2-((2S,6R,9R,11S,12S,14aR,15R,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-9-((10R,12S)-10,12-dimethyltetradecanamido)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)phenyl hydrogen phosphate


InChi Code: InChI=1S/C50H81N8O20P.Na/c1-5-25(2)20-26(3)12-10-8-6-7-9-11-13-37(65)52-31-22-35(63)46(70)56-48(72)41-33(61)18-19-57(41)50(74)39(34(62)23-36(51)64)54-47(71)40(43(67)42(66)28-14-16-30(17-15-28)78-79(75,76)77)55-45(69)32-21-29(60)24-58(32)49(73)38(27(4)59)53-44(31)68;/h14-17,25-27,29,31-35,38-43,46,59-63,66-67,70H,5-13,18-24H2,1-4H3,(H2,51,64)(H,52,65)(H,53,68)(H,54,71)(H,55,69)(H,56,72)(H2,75,76,77);/q;+1/p-1/t25-,26+,27+,29-,31+,32-,33+,34+,35-,38+,39-,40-,41+,42-,43+,46-;/m0./s1

SMILES Code: O[C@H]1C[C@@H](C(N[C@H](C(N[C@H](C(N2CC[C@H]([C@@H]2C(N[C@H]([C@H](C[C@H](C(N[C@H]([C@H](O)C)C3=O)=O)NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)O)O)=O)O)=O)[C@H](O)CC(N)=O)=O)[C@H]([C@H](c4ccc(OP([O-])(O)=O)cc4)O)O)=O)N3C1.[Na+]

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Flattery AM, Abruzzo GK, Gill CJ, Smith JG, Bartizal K. New model of oropharyngeal and gastrointestinal colonization by Candida albicans in CD4+ T-cell-deficient mice for evaluation of antifungal agents. Antimicrob Agents Chemother. 1996 Jul;40(7):1604-9. PubMed PMID: 8807048; PubMed Central PMCID: PMC163381.

2: Kurtz MB, Bernard EM, Edwards FF, Marrinan JA, Dropinski J, Douglas CM, Armstrong D. Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis. Antimicrob Agents Chemother. 1995 Aug;39(8):1784-9. PubMed PMID: 7486919; PubMed Central PMCID: PMC162826.

3: Schmatz DM, Powles MA, McFadden D, Nollstadt K, Bouffard FA, Dropinski JF, Liberator P, Andersen J. New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat. Antimicrob Agents Chemother. 1995 Jun;39(6):1320-3. PubMed PMID: 7574523; PubMed Central PMCID: PMC162734.

4: Powles MA, McFadden DC, Liberator PA, Anderson JW, Vadas EB, Meisner D, Schmatz DM. Aerosolized L-693,989 for Pneumocystis carinii prophylaxis in rats. Antimicrob Agents Chemother. 1994 Jun;38(6):1397-401. PubMed PMID: 8092844; PubMed Central PMCID: PMC188217.

5: Schmatz DM, Powles MA, McFadden DC, Pittarelli L, Balkovec J, Hammond M, Zambias R, Liberator P, Anderson J. Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats. Antimicrob Agents Chemother. 1992 Sep;36(9):1964-70. PubMed PMID: 1416888; PubMed Central PMCID: PMC192216.