L 691121

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596651

CAS#: 136075-60-0

Description: L 691121 is a class III antiarrhythmic agent which blocks potassium currents.

Chemical Structure

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L 691121
CAS# 136075-60-0
Instruction

Theoretical Analysis

MedKoo Cat#: 596651
Name: L 691121
CAS#: 136075-60-0
Chemical Formula: C22H25ClN4O5S
Exact Mass: 0.00
Molecular Weight: 492.970
Elemental Analysis: C, 53.60; H, 5.11; Cl, 7.19; N, 11.37; O, 16.23; S, 6.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 691121; L-691121; L691121; L-691,121; L 691,121; L691,121;

IUPAC/Chemical Name: N-(1'-(2-(benzo[c][1,2,5]oxadiazol-5-yl)ethyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)methanesulfonamide hydrochloride

InChi Key: NHRIUQWDVKKIAZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24N4O5S.ClH/c1-32(28,29)25-16-3-5-21-17(13-16)20(27)14-22(30-21)7-10-26(11-8-22)9-6-15-2-4-18-19(12-15)24-31-23-18;/h2-5,12-13,25H,6-11,14H2,1H3;1H

SMILES Code: CS(=O)(NC1=CC=C2C(C(CC3(CCN(CCC4=CC5=NON=C5C=C4)CC3)O2)=O)=C1)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 492.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zaniboni M, Pollard AE, Yang L, Spitzer KW. Beat-to-beat repolarization variability in ventricular myocytes and its suppression by electrical coupling. Am J Physiol Heart Circ Physiol. 2000 Mar;278(3):H677-87. PubMed PMID: 10710334.

2: Greber TF, Olah TV, Gilbert JD, Porras AG, Hichens M. Determination of L-691,121, a new class III antiarrhythmic, and its principal metabolite in plasma by differential radioimmunoassay. J Pharm Biomed Anal. 1994 Apr;12(4):483-92. PubMed PMID: 7918764.

3: Ban Y, Konishi R, Kawana K, Nakatsuka T, Fujii T, Manson JM. Embryotoxic effects of L-691,121, a class III antiarrhythmic agent, in rats. Arch Toxicol. 1994;69(1):65-71. PubMed PMID: 7717857.

4: Lynch JJ Jr, Wallace AA, Van der Gaag LH, Baskin EP, Bear CM, Gehret JR, Kothstein T, Stupienski RF, Appleby SD, Sanguinetti MC, et al. Cardiac electrophysiologic and antiarrhythmic actions of 3,4-dihydro-1'-[2-(benzofurazan-5-yl) ethyl]-6-methanesulfonamidospiro [(2H)-1-benzopyran-2,4'-piperidin]-4-one HCl (L-691,121), a novel class III agent. J Pharmacol Exp Ther. 1993 May;265(2):720-30. PubMed PMID: 8496818.

5: Vickers S, Duncan CA, Kari PH, Homnick CF, Elliott JM, Pitzenberger SM, Hichens M, Vyas KP. In vivo and in vitro metabolism studies on a class III antiarrhythmic agent. Drug Metab Dispos. 1993 May-Jun;21(3):467-73. PubMed PMID: 8100503.

6: Elliott JM, Selnick HG, Claremon DA, Baldwin JJ, Buhrow SA, Butcher JW, Habecker CN, King SW, Lynch JJ Jr, Phillips BT, et al. 4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121). J Med Chem. 1992 Oct 16;35(21):3973-6. PubMed PMID: 1433205.