L 687908

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MedKoo CAT#: 596638

CAS#: 132565-33-4

Description: L 687908 is a potent hydroxyethylene-containing HIV protease inhibitor.


Price and Availability

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Pricing updated 2020-03-29. Prices are subject to change without notice.

L 687908 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596638
Name: L 687908
CAS#: 132565-33-4
Chemical Formula: C40H51N5O5
Exact Mass: 681.389
Molecular Weight: 681.87
Elemental Analysis: C, 70.46; H, 7.54; N, 10.27; O, 11.73


Synonym: L 687908; L-687908; L687908; L-687,908; L 687,908; L687,908;

IUPAC/Chemical Name: tert-butyl ((2S,3S,5R,E)-5-((1-(((1H-benzo[d]imidazol-2-yl)methyl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-3-hydroxy-1,8-diphenyloct-7-en-2-yl)carbamate

InChi Key: XETIIHXJGVJJAT-NODMNJIGSA-N

InChi Code: InChI=1S/C40H51N5O5/c1-6-27(2)36(38(48)41-26-35-42-31-22-13-14-23-32(31)43-35)45-37(47)30(21-15-20-28-16-9-7-10-17-28)25-34(46)33(24-29-18-11-8-12-19-29)44-39(49)50-40(3,4)5/h7-20,22-23,27,30,33-34,36,46H,6,21,24-26H2,1-5H3,(H,41,48)(H,42,43)(H,44,49)(H,45,47)/b20-15+/t27?,30-,33+,34+,36?/m1/s1

SMILES Code: O=C(OC(C)(C)C)N[C@@H](CC1=CC=CC=C1)[C@@H](O)C[C@H](C(NC(C(NCC2=NC3=CC=CC=C3N2)=O)C(C)CC)=O)C/C=C/C4=CC=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kohl NE, Diehl RE, Rands E, Davis LJ, Hanobik MG, Wolanski B, Dixon RA. Expression of active human immunodeficiency virus type 1 protease by noninfectious chimeric virus particles. J Virol. 1991 Jun;65(6):3007-14. PubMed PMID: 1709693; PubMed Central PMCID: PMC240951.

2: Vacca JP, Guare JP, deSolms SJ, Sanders WM, Giuliani EA, Young SD, Darke PL, Zugay J, Sigal IS, Schleif WA, et al. L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor. J Med Chem. 1991 Mar;34(3):1225-8. PubMed PMID: 2002465.