L 680833

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596634

CAS#: 127063-08-5

Description: L 680833 is a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase.

Chemical Structure

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L 680833
CAS# 127063-08-5
Instruction

Theoretical Analysis

MedKoo Cat#: 596634
Name: L 680833
CAS#: 127063-08-5
Chemical Formula: C27H34N2O5
Exact Mass: 466.25
Molecular Weight: 466.570
Elemental Analysis: C, 69.51; H, 7.35; N, 6.00; O, 17.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 680833; L-680833; L680833; L-680,833; L 680,833; L680,833;

IUPAC/Chemical Name: 2-(4-(((S)-3,3-diethyl-4-oxo-1-(((R)-1-(p-tolyl)butyl)carbamoyl)azetidin-2-yl)oxy)phenyl)acetic acid

InChi Key: KGAREWFAONZBOP-RDGATRHJSA-N

InChi Code: InChI=1S/C27H34N2O5/c1-5-8-22(20-13-9-18(4)10-14-20)28-26(33)29-24(32)27(6-2,7-3)25(29)34-21-15-11-19(12-16-21)17-23(30)31/h9-16,22,25H,5-8,17H2,1-4H3,(H,28,33)(H,30,31)/t22-,25+/m1/s1

SMILES Code: O=C(O)CC1=CC=C(O[C@@H](C2(CC)CC)N(C(N[C@@H](C3=CC=C(C)C=C3)CCC)=O)C2=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 466.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dwyer TM, Farley JM. Human neutrophil elastase releases two pools of mucinlike glycoconjugate from tracheal submucosal gland cells. Am J Physiol Lung Cell Mol Physiol. 2000 Apr;278(4):L675-82. PubMed PMID: 10749744.

2: Macchia B, Gentili D, Macchia M, Mamone F, Martinelli A, Orlandini E, Rossello A, Cercignani G, Pierotti R, Allegretti M, Asti C, Caselli G. Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones. Eur J Med Chem. 2000 Jan;35(1):53-67. PubMed PMID: 10733603.

3: Sköld CM, Liu X, Umino T, Zhu Y, Ohkuni Y, Romberger DJ, Spurzem JR, Heires AJ, Rennard SI. Human neutrophil elastase augments fibroblast-mediated contraction of released collagen gels. Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1138-46. PubMed PMID: 10194158.

4: Rees DD, Brain JD. Effects of cystic fibrosis airway secretions on rat lung: role of neutrophil elastase. Am J Physiol. 1995 Aug;269(2 Pt 1):L195-202. PubMed PMID: 7653580.

5: Doherty JB, Shah SK, Finke PE, Dorn CP Jr, Hagmann WK, Hale JJ, Kissinger AL, Thompson KR, Brause K, Chandler GO, et al. Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8727-31. PubMed PMID: 8378355; PubMed Central PMCID: PMC47431.