L 657925

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596608

CAS#: 122757-59-9

Description: L 657925 is a thromboxane A2 receptor antagonist.


Chemical Structure

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L 657925
CAS# 122757-59-9

Theoretical Analysis

MedKoo Cat#: 596608
Name: L 657925
CAS#: 122757-59-9
Chemical Formula: C21H21ClFNO2
Exact Mass: 373.12
Molecular Weight: 373.850
Elemental Analysis: C, 67.47; H, 5.66; Cl, 9.48; F, 5.08; N, 3.75; O, 8.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L657925; L 657925; L-657925;

IUPAC/Chemical Name: 2-(9-(4-chlorobenzyl)-6-fluoro-2,3,4,4a,9,9a-hexahydro-1H-carbazol-1-yl)acetic acid

InChi Key: USFMJLOJQLMDAA-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21ClFNO2/c22-15-6-4-13(5-7-15)12-24-19-9-8-16(23)11-18(19)17-3-1-2-14(21(17)24)10-20(25)26/h4-9,11,14,17,21H,1-3,10,12H2,(H,25,26)

SMILES Code: O=C(O)CC1C2N(CC3=CC=C(Cl)C=C3)C4=C(C=C(F)C=C4)C2CCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 373.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Paul RV, Saxenhofer H, Wackym PS, Halushka PV. Stimulation of rat mesangial cell thromboxane A2 receptors inhibits particulate but not soluble guanylyl cyclase. Am J Physiol. 1996 Jan;270(1 Pt 2):F31-8. PubMed PMID: 8769820.

2: Zucker TP, Higashiura K, Mathur RS, Halushka PV. Androstenedione increases thromboxane A2 receptors in human erythroleukemia cells. Life Sci. 1996;58(8):683-90. PubMed PMID: 8594318.

3: Simmons TR, Cook JA, Moore JN, Halushka PV. Thromboxane A2 receptors in equine monocytes: identification of a new subclass of TXA2 receptors. J Leukoc Biol. 1993 Feb;53(2):173-8. PubMed PMID: 8383167.

4: Ueda N, Mayeux PR, Walker PD, Shah SV. Receptor-mediated increase in cytosolic calcium in LLC-PK1 cells by platelet activating factor and thromboxane A2. Kidney Int. 1991 Dec;40(6):1075-81. PubMed PMID: 1662319.

5: Mayeux PR, Morinelli TA, Williams TC, Hazard ES, Mais DE, Oatis JE, Baron DA, Halushka PV. Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets. J Biol Chem. 1991 Jul 25;266(21):13752-8. PubMed PMID: 1830308.