L 653328

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596603

CAS#: 115609-61-5

Description: L 653328 is an ocular hypotensive agent with modest beta receptor blocking activity.

Chemical Structure

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L 653328
CAS# 115609-61-5
Instruction

Theoretical Analysis

MedKoo Cat#: 596603
Name: L 653328
CAS#: 115609-61-5
Chemical Formula: C17H27NO4
Exact Mass: 309.19
Molecular Weight: 309.400
Elemental Analysis: C, 65.99; H, 8.80; N, 4.53; O, 20.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 653328; L-653328; L653328; L-653,328; L653,328; L 653,328;

IUPAC/Chemical Name: (S)-4-(3-(tert-butylamino)-2-hydroxypropoxy)phenethyl acetate

InChi Key: YSAYHFMJDLPBGB-HNNXBMFYSA-N

InChi Code: InChI=1S/C17H27NO4/c1-13(19)21-10-9-14-5-7-16(8-6-14)22-12-15(20)11-18-17(2,3)4/h5-8,15,18,20H,9-12H2,1-4H3/t15-/m0/s1

SMILES Code: O[C@@H](CNC(C)(C)C)COC1=CC=C(CCOC(C)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 309.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bauer KG, Brunner-Ferber F, Distlerath LM, Lippa EA, Binkowitz B, Till P, Kaik GA. Assessment of bronchial effects following topical administration of butylamino-phenoxy-propanol-acetate, an oculoselective beta-adrenoceptor blocker in asthmatic subjects. Br J Clin Pharmacol. 1992 Aug;34(2):122-9. PubMed PMID: 1358158; PubMed Central PMCID: PMC1381528.

2: Gerin G, Durand-Cavagna G, Gordon LR, Duprat P, Hollander CF. Drug-induced changes in dogs after long term application of a beta-blocker. Lens Eye Toxic Res. 1989;6(1-2):319-29. PubMed PMID: 2577307.

3: Sugrue MF, Gautheron P, Grove J, Mallorga P, Viader MP, Baldwin JJ, Ponticello GS, Varga SL. L-653,328: an ocular hypotensive agent with modest beta receptor blocking activity. Invest Ophthalmol Vis Sci. 1988 May;29(5):776-84. PubMed PMID: 2896641.