L 650719

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MedKoo CAT#: 596592

CAS#: 96803-89-3

Description: L 650719 is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-03-30. Prices are subject to change without notice.

L 650719 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596592
Name: L 650719
CAS#: 96803-89-3
Chemical Formula: C8H7NO3S2
Exact Mass: 228.9867
Molecular Weight: 229.26
Elemental Analysis: C, 41.91; H, 3.08; N, 6.11; O, 20.93; S, 27.97


Synonym: L 650719; L-650719; L650719; 6-HTS;

IUPAC/Chemical Name: 6-hydroxybenzo[b]thiophene-2-sulfonamide

InChi Key: XRZYWSVMYHEQPN-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H7NO3S2/c9-14(11,12)8-3-5-1-2-6(10)4-7(5)13-8/h1-4,10H,(H2,9,11,12)

SMILES Code: O=S(C1=CC2=CC=C(O)C=C2S1)(N)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Graham SL, Shepard KL, Anderson PS, Baldwin JJ, Best DB, Christy ME, Freedman MB, Gautheron P, Habecker CN, Hoffman JM, et al. Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. J Med Chem. 1989 Dec;32(12):2548-54. PubMed PMID: 2585443.

2: Bar-Ilan A, Pessah NI, Maren TH. Ocular hypotensive activity and disposition of the topical carbonic anhydrase inhibitor 6-hydroxy-benzo[b]thiophene-2-sulfonamide, L-650,719, in the rabbit. J Ocul Pharmacol. 1989 Summer;5(2):99-110. PubMed PMID: 2754300.

3: Grove J, Gautheron P, Plazonnet B, Sugrue MF. Ocular distribution studies of the topical carbonic anhydrase inhibitors L-643,799 and L-650,719 and related alkyl prodrugs. J Ocul Pharmacol. 1988 Winter;4(4):279-90. PubMed PMID: 3246565.

4: Werner EB, Gerber DS, Yoder YJ. Effect of a topical carbonic anhydrase inhibitor, 6-hydroxybenzo[b]thiophene-2-sulfonamide, on intraocular pressure in normotensive subjects. Can J Ophthalmol. 1987 Oct;22(6):316-9. PubMed PMID: 3322537.