L 650719

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 559094

CAS#: 96803-89-3

Description: L 650719 is a bioactive chemical.

Chemical Structure

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L 650719
CAS# 96803-89-3
Instruction

Theoretical Analysis

MedKoo Cat#: 559094
Name: L 650719
CAS#: 96803-89-3
Chemical Formula: C8H7NO3S2
Exact Mass: 228.99
Molecular Weight: 229.260
Elemental Analysis: C, 41.91; H, 3.08; N, 6.11; O, 20.93; S, 27.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 650719; L-650719; L650719; 6-HTS;

IUPAC/Chemical Name: 6-hydroxybenzo[b]thiophene-2-sulfonamide

InChi Key: XRZYWSVMYHEQPN-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H7NO3S2/c9-14(11,12)8-3-5-1-2-6(10)4-7(5)13-8/h1-4,10H,(H2,9,11,12)

SMILES Code: O=S(C1=CC2=CC=C(O)C=C2S1)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 229.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Graham SL, Shepard KL, Anderson PS, Baldwin JJ, Best DB, Christy ME, Freedman MB, Gautheron P, Habecker CN, Hoffman JM, et al. Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. J Med Chem. 1989 Dec;32(12):2548-54. PubMed PMID: 2585443.

2: Bar-Ilan A, Pessah NI, Maren TH. Ocular hypotensive activity and disposition of the topical carbonic anhydrase inhibitor 6-hydroxy-benzo[b]thiophene-2-sulfonamide, L-650,719, in the rabbit. J Ocul Pharmacol. 1989 Summer;5(2):99-110. PubMed PMID: 2754300.

3: Grove J, Gautheron P, Plazonnet B, Sugrue MF. Ocular distribution studies of the topical carbonic anhydrase inhibitors L-643,799 and L-650,719 and related alkyl prodrugs. J Ocul Pharmacol. 1988 Winter;4(4):279-90. PubMed PMID: 3246565.

4: Werner EB, Gerber DS, Yoder YJ. Effect of a topical carbonic anhydrase inhibitor, 6-hydroxybenzo[b]thiophene-2-sulfonamide, on intraocular pressure in normotensive subjects. Can J Ophthalmol. 1987 Oct;22(6):316-9. PubMed PMID: 3322537.