L-6424
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596591

CAS#: 147030-50-0

Description: L-6424 is an intermediate of Amiodarone, a non-selective ion channel blocker and an antiarrhythmic.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 450 2 Weeks
100mg USD 800 2 Weeks
250mg USD 1580 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-03-30. Prices are subject to change without notice.

L-6424 purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596591
Name: L-6424
CAS#: 147030-50-0
Chemical Formula: C19H17IO3
Exact Mass: 420.0222
Molecular Weight: 420.24
Elemental Analysis: C, 54.30; H, 4.08; I, 30.20; O, 11.42


Synonym: L-6424; L 6424; L6424; Amiodarone related compound G;

IUPAC/Chemical Name: (2-butylbenzofuran-3-yl)(4-hydroxy-3-iodophenyl)methanone

InChi Key: SPJWRQCARFHMEB-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17IO3/c1-2-3-7-17-18(13-6-4-5-8-16(13)23-17)19(22)12-9-10-15(21)14(20)11-12/h4-6,8-11,21H,2-3,7H2,1H3

SMILES Code: O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC=C(O)C(I)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Garcia-Doval C, Castón JR, Luque D, Granell M, Otero JM, Llamas-Saiz AL, Renouard M, Boulanger P, van Raaij MJ. Structure of the Receptor-Binding Carboxy-Terminal Domain of the Bacteriophage T5 L-Shaped Tail Fibre with and without Its Intra-Molecular Chaperone. Viruses. 2015 Dec 8;7(12):6424-40. doi: 10.3390/v7122946. PubMed PMID: 26670244; PubMed Central PMCID: PMC4690869.

2: Pana ZD, Samarah F, Papi R, Antachopoulos C, Papageorgiou T, Farmaki E, Hatzipantelis E, Tragiannidis A, Vavatsi-Christaki N, Kyriakidis D, Athanassiadou-Piperopoulou F, Roilides E. Mannose binding lectin and ficolin-2 polymorphisms are associated with increased risk for bacterial infections in children with B acute lymphoblastic leukemia. Pediatr Blood Cancer. 2014 Jun;61(6):1017-22. doi: 10.1002/pbc.24951. Epub 2014 Jan 22. PubMed PMID: 24453114.

3: Kilpatrick DC, St Swierzko A, Matsushita M, Domzalska-Popadiuk I, Borkowska-Klos M, Szczapa J, Cedzynski M. The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates. Hum Immunol. 2013 Jul;74(7):867-71. doi: 10.1016/j.humimm.2013.04.011. Epub 2013 Apr 22. PubMed PMID: 23619474.

4: Harada H, Yamashita Y, Misumi K, Tsubokawa N, Nakao J, Matsutani J, Yamasaki M, Ohkawachi T, Taniyama K. Multidisciplinary team-based approach for comprehensive preoperative pulmonary rehabilitation including intensive nutritional support for lung cancer patients. PLoS One. 2013;8(3):e59566. doi: 10.1371/journal.pone.0059566. Epub 2013 Mar 15. PubMed PMID: 23555043; PubMed Central PMCID: PMC3598743.

5: Szala A, St Swierzko A, Cedzynski M. Cost-effective procedures for genotyping of human FCN2 gene single nucleotide polymorphisms. Immunogenetics. 2013 Jun;65(6):439-46. doi: 10.1007/s00251-013-0696-7. Epub 2013 Mar 23. PubMed PMID: 23525825; PubMed Central PMCID: PMC3651822.

6: Tang H, Gong Y, Mao Y, Xie Q, Zheng M, Wang D, Zhu H, Wang X, Chen H, Chen X, Zhou L. CD133-positive cells might be responsible for efficient proliferation of human meningioma cells. Int J Mol Sci. 2012;13(5):6424-39. doi: 10.3390/ijms13056424. Epub 2012 May 23. PubMed PMID: 22754374; PubMed Central PMCID: PMC3382801.

7: Gerrits PO, Veening JG. Leonardo da Vinci's "A skull sectioned": skull and dental formula revisited. Clin Anat. 2013 May;26(4):430-5. doi: 10.1002/ca.22060. Epub 2012 Mar 19. PubMed PMID: 22431331.

8: Lee JR, Jeoung JW, Choi J, Choi JY, Park KH, Kim YD. Structure-function relationships in normal and glaucomatous eyes determined by time- and spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6424-30. doi: 10.1167/iovs.09-5130. Epub 2010 Jun 30. PubMed PMID: 20592233.

9: Kawanishi M, Takamura-Enya T, Ermawati R, Shimohara C, Sakamoto M, Matsukawa K, Matsuda T, Murahashi T, Matsui S, Wakabayashi K, Watanabe T, Tashiro HY, Yagi T. Detection of genistein as an estrogenic contaminant of river water in Osaka. Environ Sci Technol. 2004 Dec 1;38(23):6424-9. PubMed PMID: 15597900.

10: Goldstein EJ, Citron DM, Merriam CV, Warren YA, Tyrrell KL, Fernandez HT. In vitro activities of the new semisynthetic glycopeptide telavancin (TD-6424), vancomycin, daptomycin, linezolid, and four comparator agents against anaerobic gram-positive species and Corynebacterium spp. Antimicrob Agents Chemother. 2004 Jun;48(6):2149-52. PubMed PMID: 15155214; PubMed Central PMCID: PMC415607.

11: King A, Phillips I, Kaniga K. Comparative in vitro activity of telavancin (TD-6424), a rapidly bactericidal, concentration-dependent anti-infective with multiple mechanisms of action against Gram-positive bacteria. J Antimicrob Chemother. 2004 May;53(5):797-803. Epub 2004 Mar 17. PubMed PMID: 15028667.

12: Ward PL, Taddeo B, Markovitz NS, Roizman B. Identification of a novel expressed open reading frame situated between genes U(L)20 and U(L)21 of the herpes simplex virus 1 genome. Virology. 2000 Jan 20;266(2):275-85. PubMed PMID: 10639314.

13: Fuchs W, Klupp BG, Granzow H, Mettenleiter TC. The UL20 gene product of pseudorabies virus functions in virus egress. J Virol. 1997 Jul;71(7):5639-46. PubMed PMID: 9188641; PubMed Central PMCID: PMC191809.

14: Avitabile E, Di Gaeta S, Torrisi MR, Ward PL, Roizman B, Campadelli-Fiume G. Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis. J Virol. 1995 Dec;69(12):7472-82. PubMed PMID: 7494253; PubMed Central PMCID: PMC189685.

15: Montagnier to assess French AIDS effort. Nature. 1993 May 6;363(6424):9. PubMed PMID: 8479543.

16: Omura S, Nakagawa A, Aoyama H, Iwai Y, Kuwahara M, Furusato T. Karabemycin, a new antimetabolite of glutamine produced by a strain of streptomycete. J Antibiot (Tokyo). 1983 Sep;36(9):1129-35. PubMed PMID: 6138342.