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MedKoo CAT#: 562907

CAS#: 1620203-63-5

Description: VU0431316 is a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.

Price and Availability

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Pricing updated 2020-10-20. Prices are subject to change without notice.

VU0431316 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 562907
Name: VU0431316
CAS#: 1620203-63-5
Chemical Formula: C14H9ClN6O2
Exact Mass: 328.0476
Molecular Weight: 328.71
Elemental Analysis: C, 51.15; H, 2.76; Cl, 10.78; N, 25.57; O, 9.73

Synonym: VU0431316; VU-0431316; VU 0431316;

IUPAC/Chemical Name: 4-Chloro-pyridine-2-carboxylic acid [6-(pyrimidin-5-yloxy)-pyrazin-2-yl]-amide


InChi Code: InChI=1S/C14H9ClN6O2/c15-9-1-2-19-11(3-9)14(22)21-12-6-16-7-13(20-12)23-10-4-17-8-18-5-10/h1-8H,(H,20,21,22)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Bates BS, Rodriguez AL, Felts AS, Morrison RD, Venable DF, Blobaum AL, Byers FW, Lawson KP, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA. Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3307-14. doi: 10.1016/j.bmcl.2014.06.003. Epub 2014 Jun 11. PubMed PMID: 24969015; PubMed Central PMCID: PMC4090943.