L 649923

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MedKoo CAT#: 596587

CAS#: 91541-81-0

Description: L 649923 is a bioactive chemical.


Price and Availability

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Pricing updated 2020-04-07. Prices are subject to change without notice.

L 649923 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596587
Name: L 649923
CAS#: 91541-81-0
Chemical Formula: C25H31NaO6S
Exact Mass: 482.1739
Molecular Weight: 482.56
Elemental Analysis: C, 62.22; H, 6.48; Na, 4.76; O, 19.89; S, 6.64


Synonym: L 649923; L-649923; L649923;

IUPAC/Chemical Name: sodium (3S,4R)-4-(4-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)phenyl)-4-hydroxy-3-methylbutanoate

InChi Key: HYMFDMFIXDCBBD-HCGKRMLVSA-M

InChi Code: InChI=1S/C25H32O6S.Na/c1-4-6-21-22(12-11-20(17(3)26)25(21)30)31-13-5-14-32-19-9-7-18(8-10-19)24(29)16(2)15-23(27)28;/h7-12,16,24,29-30H,4-6,13-15H2,1-3H3,(H,27,28);/q;+1/p-1/t16-,24+;/m0./s1

SMILES Code: O=C([O-])C[C@H](C)[C@@H](O)C1=CC=C(SCCCOC2=CC=C(C(C)=O)C(O)=C2CCC)C=C1.[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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2: Jorgensen NK, Lambert IH, Hoffmann EK. Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. J Membr Biol. 1996 May;151(2):159-73. PubMed PMID: 8661498.

3: Cicala C, Cirino G. Phospholipase A2-induced hypotension in the rat and its pharmacological modulation. Gen Pharmacol. 1993 Sep;24(5):1197-202. PubMed PMID: 8270179.

4: Leikauf GD. Mechanisms of aldehyde-induced bronchial reactivity: role of airway epithelium. Res Rep Health Eff Inst. 1992 Feb;(49):1-35. PubMed PMID: 1315139.

5: Hu WM, Man RY. Interaction of vasoactive substances released by platelet-activating factor in the rat perfused heart. Br J Pharmacol. 1991 Dec;104(4):933-7. PubMed PMID: 1810604; PubMed Central PMCID: PMC1908832.

6: Perico N, Pasini M, Gaspari F, Abbate M, Remuzzi G. Co-participation of thromboxane A2 and leukotriene C4 and D4 in mediating cyclosporine-induced acute renal failure. Transplantation. 1991 Nov;52(5):873-8. PubMed PMID: 1835198.

7: Perico N, Cornejo RP, Benigni A, Malanchini B, Ladny JR, Remuzzi G. Endothelin induces diuresis and natriuresis in the rat by acting on proximal tubular cells through a mechanism mediated by lipoxygenase products. J Am Soc Nephrol. 1991 Jul;2(1):57-69. PubMed PMID: 1655094.

8: Hu W, Kinnaird AA, Man RY. Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart. Br J Pharmacol. 1991 May;103(1):1097-102. PubMed PMID: 1652337; PubMed Central PMCID: PMC1908074.

9: Chiono M, Heller RS, Andazola JJ, Herman CA. Leukotriene C4 binds to receptors and has positive inotropic effects in bullfrog heart. J Pharmacol Exp Ther. 1991 Mar;256(3):1042-8. PubMed PMID: 2005570.

10: Cicala C, Sorrentino R, Sorrentino L, Cirino G. Effect of L-649, 923, an LTD4 antagonist, on phospholipase A2-induced hypotension. Pharmacol Res. 1990 Sep-Oct;22 Suppl 3:83. PubMed PMID: 2097660.

11: Wallace JL, McKnight GW, Keenan CM, Byles NI, MacNaughton WK. Effects of leukotrienes on susceptibility of the rat stomach to damage and investigation of the mechanism of action. Gastroenterology. 1990 May;98(5 Pt 1):1178-86. PubMed PMID: 2157619.

12: Flowers BK, Proud D, Kagey-Sobotka A, Lichtenstein LM, Naclerio RM. The effect of a leukotriene antagonist on the early response to antigen. Otolaryngol Head Neck Surg. 1990 Mar;102(3):219-24. PubMed PMID: 2108408.

13: Fraser DG, Regal JF. C5a/C5ades-Arg-induced increase in blood pressure in the guinea pig: role of thromboxane. Immunopharmacology. 1990 Jan-Feb;19(1):59-68. PubMed PMID: 1968450.

14: Cirino G, Peers SH, Wallace JL, Flower RJ. A study of phospholipase A2-induced oedema in rat paw. Eur J Pharmacol. 1989 Aug 3;166(3):505-10. PubMed PMID: 2806373.

15: Leikauf GD, Doupnik CA, Leming LM, Wey HE. Sulfidopeptide leukotrienes mediate acrolein-induced bronchial hyperresponsiveness. J Appl Physiol (1985). 1989 Apr;66(4):1838-45. PubMed PMID: 2543658.

16: Cassin S, Gause G, Davis T, ter Riet M, Baker R. Do inhibitors of lipoxygenase and cyclooxygenase block neonatal hypoxic pulmonary vasoconstriction? J Appl Physiol (1985). 1989 Apr;66(4):1779-84. PubMed PMID: 2499569.

17: Sirén AL, Eimerl J, Feuerstein G. L-649,923: an antagonist of cardiac and vascular leukotriene D4 receptors. J Cardiovasc Pharmacol. 1989 Feb;13(2):210-7. PubMed PMID: 2468948.

18: Knutson L, Nimbratt C, Flemström G. Effects of leukotriene D4, the antagonist L-649-923, and arachidonic acid on duodenal bicarbonate secretion in the rat in vivo. Scand J Gastroenterol. 1988 Dec;23(10):1225-31. PubMed PMID: 3249920.

19: Del Monte M, Subissi A. Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites. Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):417-21. PubMed PMID: 3149718.

20: Jacques CA, Spur BW, Crea AE, Lee TH. The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. Br J Pharmacol. 1988 Oct;95(2):562-8. PubMed PMID: 2852525; PubMed Central PMCID: PMC1854178.