L 648051

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MedKoo CAT#: 596586

CAS#: 91541-18-3

Description: L 648051 is an antagonist of leukotriene D4 receptor.


Price and Availability

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Pricing updated 2020-04-07. Prices are subject to change without notice.

L 648051 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596586
Name: L 648051
CAS#: 91541-18-3
Chemical Formula: C24H28O8S
Exact Mass: 476.1505
Molecular Weight: 476.54
Elemental Analysis: C, 60.49; H, 5.92; O, 26.86; S, 6.73


Synonym: L 648051; L48051; L-648051; 4-Apsob;

IUPAC/Chemical Name: 4-(4-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl)phenyl)-4-oxobutanoic acid

InChi Key: ZAKKEARLDPTRLX-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H28O8S/c1-3-5-20-22(12-10-19(16(2)25)24(20)29)32-14-4-15-33(30,31)18-8-6-17(7-9-18)21(26)11-13-23(27)28/h6-10,12,29H,3-5,11,13-15H2,1-2H3,(H,27,28)

SMILES Code: O=C(O)CCC(C1=CC=C(S(=O)(CCCOC2=CC=C(C(C)=O)C(O)=C2CCC)=O)C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Gök S, Ulker S, Evinç A. Possible contribution of leukotrienes in the arrhythmogenic effects of digoxin on isolated guinea-pig hearts. Pharmacology. 1998 Nov;57(5):279-84. PubMed PMID: 9742293.

2: Gök S, Banoaglu N. Effects of a leukotriene D4 receptor antagonist, L-648,051, and a dual inhibitor lypoxygenase and cyclooxygenase, BW-755C, on digoxin-induced arrhythmias in guinea-pigs. Arch Int Pharmacodyn Ther. 1993 Jan-Feb;321:72-80. PubMed PMID: 8391788.

3: Rasmussen JB, Eriksson LO, Tagari P, Margolskee DJ, Girard Y, Andersson KE. Urinary LTE4 excretion in antigen-provoked asthmatic patients treated with the inhaled LTD4 antagonist, L-648,051. Allergy. 1992 Dec;47(6):599-603. PubMed PMID: 1337423.

4: Rasmussen JB, Eriksson LO, Tagari P, Stahl EG, Andersson KE. Reduced nonspecific bronchial reactivity and decreased airway response to antigen challenge in atopic asthmatic patients treated with the inhaled leukotriene D4 antagonist, L-648,051. Allergy. 1992 Dec;47(6):604-9. PubMed PMID: 1285568.

5: Miura T, Inagaki N, Goto S, Yoshida K, Nagai H, Koda A. Leukotriene receptors in the skin of rats differ from those of mouse skin or rat stomach strip. Eur J Pharmacol. 1992 Oct 20;221(2-3):333-42. PubMed PMID: 1330627.

6: Lindén A, Löfdahl CG, Ullman A, Skoogh BE. In vitro characteristics of spontaneous airway tone in the guinea-pig. Acta Physiol Scand. 1991 Jul;142(3):351-7. PubMed PMID: 1656702.

7: Rasmussen JB, Eriksson LO, Andersson KE. Reversal and prevention of airway response to antigen challenge by the inhaled leukotriene D4 antagonist (L-648,051) in patients with atopic asthma. Allergy. 1991 May;46(4):266-73. PubMed PMID: 1897688.

8: Bel EH, Timmers MC, Dijkman JH, Stahl EG, Sterk PJ. The effect of an inhaled leukotriene antagonist, L-648,051, on early and late asthmatic reactions and subsequent increase in airway responsiveness in man. J Allergy Clin Immunol. 1990 Jun;85(6):1067-75. PubMed PMID: 2191993.

9: Evans JM, Barnes NC, Zakrzewski JT, Sciberras DG, Stahl EG, Piper PJ, Costello JF. L-648,051, a novel cysteinyl-leukotriene antagonist is active by the inhaled route in man. Br J Clin Pharmacol. 1989 Aug;28(2):125-35. PubMed PMID: 2775617; PubMed Central PMCID: PMC1379893.

10: Thomas HM 3rd, Sourour MS, Lopez D, Foster SH. Antagonism of leukotriene receptors and administration of a 5-lipoxygenase inhibitor do not affect hypoxic vasoconstriction. Lung. 1989;167(3):187-98. PubMed PMID: 2567790.

11: Björck T, Dahlén SE. Evidence indicating that leukotrienes C4, D4 and E4 are major mediators of contraction induced by anti-IgE in human bronchi. Agents Actions. 1989 Jan;26(1-2):87-9. PubMed PMID: 2540649.

12: Tocco DJ, Duncan AE, deLuna FA, Wells G. The physiological disposition of aerosolized 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoate (L-648,051) in rats. Drug Metab Dispos. 1988 Sep-Oct;16(5):697-700. PubMed PMID: 2906592.

13: Tocco DJ, deLuna FA, Duncan AE, Ramjit HG, Pitzenberger SM, Hsieh JY. Disposition and metabolism of sodium 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoate in rats and dogs. Drug Metab Dispos. 1988 Sep-Oct;16(5):690-6. PubMed PMID: 2906591.

14: Jones TR, Charette L, Denis D. Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor. Can J Physiol Pharmacol. 1988 Jun;66(6):762-8. PubMed PMID: 2844372.

15: Young RN. L-648,051, a potent and specific aerosol active leukotriene D4 antagonist. Agents Actions Suppl. 1988;23:113-9. PubMed PMID: 2845747.

16: Barnes N, Evans J, Zakrzewski J, Piper P, Costello J. Studies of leukotriene antagonists and synthesis inhibitors in man. Prog Clin Biol Res. 1988;263:393-403. Review. PubMed PMID: 2837778.

17: Biollaz J, Stahl E, Hsieh JY, Distlerath L, Jaeger A, Leuenberger P, Schelling JL. Tolerability and pharmacokinetics of L-648,051. A leukotriene D4-receptor antagonist, in healthy volunteers. Eur J Clin Pharmacol. 1988;33(6):603-7. PubMed PMID: 2835245.

18: Rothwell CM, Hsieh JY, Bayne WF. High-performance liquid chromatographic determination of 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoic acid and metabolites in human plasma. J Chromatogr. 1987 Jul 3;417(2):447-51. PubMed PMID: 2821046.

19: Garceau D, Ford-Hutchinson AW. The role of leukotriene D4 as a mediator of allergic conjunctivitis in the guinea-pig. Eur J Pharmacol. 1987 Feb 24;134(3):285-92. PubMed PMID: 3569415.

20: Young RN, Jones TR, Atkinson JG, Bélanger P, Champion E, Denis D, DeHaven RN, Ford-Hutchinson AW, Fortin R, Frenette R, et al. Novel arylthio- and arylsulfonylpropyloxyacetophenones: design and synthesis of L-648,051 and L-649,923, potent antagonists of leukotriene D4. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:544-8. PubMed PMID: 2959111.