L 641953

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MedKoo CAT#: 596585

CAS#: 89825-69-4

Description: L 641953 is a thromboxane receptor antagonist.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-30. Prices are subject to change without notice.

L 641953 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596585
Name: L 641953
CAS#: 89825-69-4
Chemical Formula: C15H9FO3S
Exact Mass: 288.0256
Molecular Weight: 288.29
Elemental Analysis: C, 62.49; H, 3.15; F, 6.59; O, 16.65; S, 11.12


Synonym: L 641953; L-641953; L641953;

IUPAC/Chemical Name: (R)-8-fluorodibenzo[b,f]thiepine-3-carboxylic acid 5-oxide

InChi Key: SAHGCTPARQWSQG-HXUWFJFHSA-N

InChi Code: InChI=1S/C15H9FO3S/c16-12-5-6-13-10(7-12)3-1-9-2-4-11(15(17)18)8-14(9)20(13)19/h1-8H,(H,17,18)/t20-/m1/s1

SMILES Code: O=C(C1=CC=C(C=CC2=CC(F)=CC=C23)C([S@@]3=O)=C1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Welch WJ, Wilcox CS, Dunbar KR. Modulation of renin by thromboxane: studies with thromboxane synthase inhibitor, receptor antagonists, and mimetic. Am J Physiol. 1989 Oct;257(4 Pt 2):F554-60. PubMed PMID: 2508488.

2: Hall RA, Rokach JR, Bélanger P, Bianchi L, Ethier D, Ford-Hutchinson AW, Girard Y, Hamel P, Hamel R, Lord A, et al. L-641,953 (R-8-fluoro-dibenzo[b, f]thiepin-3-carboxylic acid-5-oxide): a novel thromboxane-prostaglandin endoperoxide antagonist. Can J Physiol Pharmacol. 1987 Apr;65(4):509-14. PubMed PMID: 3607600.