L 645151

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MedKoo CAT#: 596582

CAS#: 86394-94-7

Description: L 645151 is a lipophilic CA inhibitor.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-04-07. Prices are subject to change without notice.

L 645151 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596582
Name: L 645151
CAS#: 86394-94-7
Chemical Formula: C12H14N2O4S2
Exact Mass: 314.0395
Molecular Weight: 314.37
Elemental Analysis: C, 45.85; H, 4.49; N, 8.91; O, 20.36; S, 20.40


Synonym: L 645151; L-645151; L645151;

IUPAC/Chemical Name: 2-sulfamoylbenzo[d]thiazol-6-yl pivalate

InChi Key: FAZPZNCEAZRGPY-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14N2O4S2/c1-12(2,3)10(15)18-7-4-5-8-9(6-7)19-11(14-8)20(13,16)17/h4-6H,1-3H3,(H2,13,16,17)

SMILES Code: CC(C)(C)C(OC1=CC=C2N=C(S(=O)(N)=O)SC2=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Wetzel P, Kleinke T, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase slows the Ca(2+) transient in rat skeletal muscle fibers. Am J Physiol Cell Physiol. 2002 Oct;283(4):C1242-53. PubMed PMID: 12225987.

2: Wetzel P, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres. Pflugers Arch. 2002 Mar;443(5-6):762-70. Epub 2002 Jan 22. PubMed PMID: 11889574.

3: Woltersdorf OW Jr, Schwam H, Bicking JB, Brown SL, deSolms SJ, Fishman DR, Graham SL, Gautheron PD, Hoffman JM, Larson RD, et al. Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide. J Med Chem. 1989 Nov;32(11):2486-92. PubMed PMID: 2810337.

4: Bar-Ilan A, Pessah NI, Maren TH. Ocular penetration and hypotensive activity of the topically applied carbonic anhydrase inhibitor L-645,151. J Ocul Pharmacol. 1986 Spring;2(2):109-20. PubMed PMID: 3503100.

5: Sugrue MF, Gautheron P, Schmitt C, Viader MP, Conquet P, Smith RL, Share NN, Stone CA. On the pharmacology of L-645,151: a topically effective ocular hypotensive carbonic anhydrase inhibitor. J Pharmacol Exp Ther. 1985 Feb;232(2):534-40. PubMed PMID: 3838190.