L 645164

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MedKoo CAT#: 596580

CAS#: 85493-98-7

Description: L 645164 is a hydroxymethylglutaryl-CoA reductase inhibitor.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-04-07. Prices are subject to change without notice.

L 645164 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596580
Name: L 645164
CAS#: 85493-98-7
Chemical Formula: C22H23FO3
Exact Mass: 354.1631
Molecular Weight: 354.42
Elemental Analysis: C, 74.56; H, 6.54; F, 5.36; O, 13.54

Synonym: L 645164; L-645164; L645164;

IUPAC/Chemical Name: (4R,6S)-6-((E)-2-(4'-fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one


InChi Code: InChI=1S/C22H23FO3/c1-13-8-14(2)19(6-5-18-11-17(24)12-22(25)26-18)20(9-13)16-4-7-21(23)15(3)10-16/h4-10,17-18,24H,11-12H2,1-3H3/b6-5+/t17-,18-/m1/s1

SMILES Code: O=C1C[C@H](O)C[C@@H](/C=C/C2=C(C)C=C(C)C=C2C3=CC=C(F)C(C)=C3)O1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Gerson RJ, Allen HL, Lankas GR, MacDonald JS, Alberts AW, Bokelman DL. The toxicity of a fluorinated-biphenyl HMG-CoA reductase inhibitor in beagle dogs. Fundam Appl Toxicol. 1991 Feb;16(2):320-9. PubMed PMID: 2055362.

2: Gerson RJ, MacDonald JS, Alberts AW, Chen J, Yudkovitz JB, Greenspan MD, Rubin LF, Bokelman DL. On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors. Exp Eye Res. 1990 Jan;50(1):65-78. PubMed PMID: 2307197.