L 643441

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MedKoo CAT#: 596577

CAS#: 78442-39-4

Description: L 643441 is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-30. Prices are subject to change without notice.

L 643441 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596577
Name: L 643441
CAS#: 78442-39-4
Chemical Formula: C17H25N5O2S
Exact Mass: 363.1729
Molecular Weight: 363.48
Elemental Analysis: C, 56.18; H, 6.93; N, 19.27; O, 8.80; S, 8.82


Synonym: L 643441; L-643441; L643441; L-643,441; L 643,441; L643,441;

IUPAC/Chemical Name: 3-amino-4-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)-1,2,5-thiadiazole 1-oxide

InChi Key: DUPAVAVETJQPOR-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H25N5O2S/c18-16-17(21-25(23)20-16)19-8-5-11-24-15-7-4-6-14(12-15)13-22-9-2-1-3-10-22/h4,6-7,12H,1-3,5,8-11,13H2,(H2,18,20)(H,19,21)

SMILES Code: NC1=NS(N=C1NCCCOC2=CC=CC(CN3CCCCC3)=C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Wang RW, Miwa GT, Argenbright LS, Lu AY. In vitro studies on the interaction of famotidine with liver microsomal cytochrome P-450. Biochem Pharmacol. 1988 Aug 1;37(15):3049-53. PubMed PMID: 2899433.

2: Reeves JJ, Stables R. The antisecretory profile of action of the H2-receptor antagonists, famotidine, loxtidine, ranitidine and L-643,441 on the rat isolated gastric mucosa. Agents Actions. 1987 Feb;20(1-2):22-8. PubMed PMID: 2883848.

3: Lin JH, Cocchetto DM, Yeh KC, Duggan DE. Comparative effects of H2-receptor antagonists on drug interaction in rats. Drug Metab Dispos. 1986 Nov-Dec;14(6):649-53. PubMed PMID: 2877821.

4: MacLeod KM, Wenkstern D, McNeill JH. Irreversible antagonism of histamine H2 receptors in guinea-pig myocardium. Eur J Pharmacol. 1986 May 27;124(3):331-6. PubMed PMID: 2874036.

5: Henry DA, Somerville KW, Kitchingman GK, Holmes IB, Tobert JA, Langman MJ. L-643.441: an H2-receptor antagonist with potent and long-lasting effects in man. Br J Clin Pharmacol. 1985 Aug;20(2):133-6. PubMed PMID: 2864050; PubMed Central PMCID: PMC1400675.

6: Pendleton RG, Cook PG, Shepherd-Rose A, Mangel AW. Effects of H2-receptor antagonists upon physiological acid secretory states in animals. J Pharmacol Exp Ther. 1985 Apr;233(1):64-9. PubMed PMID: 2858583.

7: Batzri S, Thompson WF, Toles R. Distortion of H2-antagonist equilibrium constants by uptake in rabbit gastric mucosal cells. Pharmacology. 1985;30(4):215-24. PubMed PMID: 2859616.

8: Shepherd-Rose AJ, Pendleton RG. Studies on the properties of 3-N-[3-[3-(1-piperidinomethyl)phenoxy]-propyl]amino-4-amino-1,2, 5-thiadiazole-1-oxide (L-643,441) as an H2-receptor antagonist in isolated gastric glands. Eur J Pharmacol. 1984 Oct 1;105(1-2):57-63. PubMed PMID: 6149144.

9: Batzri S, Harmon JW, Toles R. Comparison of cimetidine with new H2-antagonists in rabbit and guinea pig gastric cells. Eur J Pharmacol. 1983 Oct 14;94(1-2):1-8. PubMed PMID: 6140169.

10: Torchiana ML, Pendleton RG, Cook PG, Hanson CA, Clineschmidt BV. Apparent irreversible H2-receptor blocking and prolonged gastric antisecretory activities of 3-N-(3-[3-(1-piperidinomethyl)phenoxy]propyl) amino-4-amino-1,2,5-thiadiazole-1-oxide (L-643, 441). J Pharmacol Exp Ther. 1983 Mar;224(3):514-9. PubMed PMID: 6131118.