L 640876

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596576

CAS#: 77527-71-0

Description: L 640876 is a semisynthetic antibiotic.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-03-30. Prices are subject to change without notice.

L 640876 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596576
Name: L 640876
CAS#: 77527-71-0
Chemical Formula: C22H21N7O3S2
Exact Mass: 495.1147
Molecular Weight: 495.57
Elemental Analysis: C, 53.32; H, 4.27; N, 19.78; O, 9.69; S, 12.94


Synonym: L 640876; L-640876; L640876; L-640,876; L 640,876; L640,876;

IUPAC/Chemical Name: (6R,7R)-7-((1-benzylpyridin-1-ium-4-yl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

InChi Key: MZRVUZHPHNYXTK-YLJYHZDGSA-N

InChi Code: InChI=1S/C22H21N7O3S2/c1-27-22(24-25-26-27)34-13-15-12-33-20-17(19(30)29(20)18(15)21(31)32)23-16-7-9-28(10-8-16)11-14-5-3-2-4-6-14/h2-10,17,20H,11-13H2,1H3,(H,31,32)/t17-,20-/m1/s1

SMILES Code: O=C1[C@@H](NC2=CC=[N+](CC3=CC=CC=C3)C=C2)[C@@]4([H])SCC(CSC5=NN=NN5C)=C(C([O-])=O)N14


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Jacks TM, Schleim KD, Miller BM, Shungu DL, Weinberg E, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. V. L-640,876 treatment of induced enterotoxigenic colibacillosis (scours) in calves and piglets. J Antibiot (Tokyo). 1983 Jan;36(1):70-5. PubMed PMID: 6381448.

2: Koupal LR, Pelak BA, Cassidy PJ, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. III. The mode of action of L-640,876 and the effect of NaCl on membrane permeability and binding. J Antibiot (Tokyo). 1983 Jan;36(1):54-63. PubMed PMID: 6381447.

3: Celozzi E, Pelak BA, Stapley EO, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. IV. Comparison of the in vivo antibacterial activities of L-640,876, mecillinam, cefoxitin and cefotaxime. J Antibiot (Tokyo). 1983 Jan;36(1):64-9. PubMed PMID: 6088459.

4: Koupal LR, Weissberger B, Shungu DL, Weinberg E, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. II. The in vitro antibacterial properties of L-640,876, a new type of beta-lactam antibiotic. J Antibiot (Tokyo). 1983 Jan;36(1):47-53. PubMed PMID: 6088458.