L 640035

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MedKoo CAT#: 596575

CAS#: 77167-93-2

Description: L 640035 inhibits human platelet aggregation induced by arachidonic acid, collagen & prostaglandin endoperoxide analog of U44069.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-30. Prices are subject to change without notice.

L 640035 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596575
Name: L 640035
CAS#: 77167-93-2
Chemical Formula: C15H12O3S
Exact Mass: 272.0507
Molecular Weight: 272.31
Elemental Analysis: C, 66.16; H, 4.44; O, 17.63; S, 11.77

Synonym: L 640035; L-640035; L640035; L-640,035; L 640,035; L640,035;

IUPAC/Chemical Name: 3-(hydroxymethyl)dibenzo[b,f]thiepine 5,5-dioxide


InChi Code: InChI=1S/C15H12O3S/c16-10-11-5-6-13-8-7-12-3-1-2-4-14(12)19(17,18)15(13)9-11/h1-9,16H,10H2

SMILES Code: OCC1=CC=C(C=CC2=CC=CC=C23)C(S3(=O)=O)=C1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Swayne GT, Maguire J, Dolan J, Raval P, Dane G, Greener M, Owen DA. Evidence for homogeneity of thromboxane A2 receptor using structurally different antagonists. Eur J Pharmacol. 1988 Aug 2;152(3):311-9. PubMed PMID: 2975605.

2: Khirabadi BS, Foegh ML, Goldstein HA, Ramwell PW. The effect of prednisolone, thromboxane, and platelet-activating factor receptor antagonists on lymphocyte and platelet migration in experimental cardiac transplantation. Transplantation. 1987 May;43(5):626-30. PubMed PMID: 3033853.

3: Ganey PE, Roth RA. Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole. Am J Physiol. 1987 Apr;252(4 Pt 2):H743-8. PubMed PMID: 2952022.

4: Melki TS, Foegh ML, Ramwell PW. Implication of thromboxane in frusemide diuresis in rats. Clin Sci (Lond). 1986 Dec;71(6):647-50. PubMed PMID: 3791866.

5: Foegh ML, Khirabadi BS, Ramwell PW. Platelet deposition in rat heart allografts and the effect of a thromboxane receptor antagonist. J Heart Transplant. 1986 Jul-Aug;5(4):338-9. PubMed PMID: 2957473.

6: Foegh ML, Khirabadi B, Ramwell PW. Prolongation of experimental cardiac allograft survival with thromboxane-related drugs. Transplantation. 1985 Aug;40(2):124-5. PubMed PMID: 3161224.

7: Chan CC, Ford-Hutchinson A. Potentiation of the inhibitory effect of a thromboxane A2 antagonist (L-640,035) on arterial thrombosis formation in rabbit by the angiotensin converting enzyme inhibitor enalapril. Eur J Pharmacol. 1985 Apr 16;110(3):323-8. PubMed PMID: 2988983.

8: Slobodzian DK, Hsieh JY, Bayne WF. High-performance liquid chromatographic determination of 3-hydroxymethyl-dibenzo[b,f]thiepin 5,5-dioxide and its acid metabolite in human plasma and urine. J Chromatogr. 1985 Feb 27;338(1):253-8. PubMed PMID: 4019653.

9: Foegh ML, Alijani MR, Helfrich GB, Khirabadi BS, Goldman MH, Lower RR, Ramwell PW. Thromboxane and leukotrienes in clinical and experimental transplant rejection. Adv Prostaglandin Thromboxane Leukot Res. 1985;13:209-17. PubMed PMID: 2988310.

10: Foegh ML, Alijani MR, Helfrich GB, Khirabadi BS, Ramwell PW. Prolongation of cardiac allograft survival with the PAF antagonist BN-52021 and the thromboxane receptor antagonists L640035 and L636499. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:381-4. PubMed PMID: 2936126.

11: Lefer AM, Burke SE, Lepran I. Preservation of ischemic myocardial tissue with an antagonist of vasoconstrictor eicosanoids. Can J Physiol Pharmacol. 1984 Dec;62(12):1487-91. PubMed PMID: 6241500.

12: McFarlane CS, Piechuta H, Hall RA, Ford-Hutchinson AW. Effects of a contractile prostaglandin antagonist (L-640,035) upon allergen-induced bronchoconstriction in hyperreactive rats and conscious squirrel monkeys. Prostaglandins. 1984 Aug;28(2):173-82. PubMed PMID: 6505224.

13: Carrier R, Cragoe EJ, Ethier D, Ford-Hutchinson AW, Girard Y, Hall RA, Hamel P, Rokach J, Share NN, Stone CA, et al. Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung. Br J Pharmacol. 1984 Jun;82(2):389-95. PubMed PMID: 6428502; PubMed Central PMCID: PMC1987036.

14: Chan CC, Nathaniel DJ, Yusko PJ, Hall RA, Ford-Hutchinson AW. Inhibition of prostanoid-mediated platelet aggregation in vivo and in vitro by 3-hydroxymethyl-dibenzo(b,f)thiepin 5,5-dioxide (L-640,035). J Pharmacol Exp Ther. 1984 Apr;229(1):276-82. PubMed PMID: 6423813.