L 644257

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MedKoo CAT#: 596574

CAS#: 68354-99-4

Description: L 644257 is a synthetic glycolipid for the study of in vivo behavior of liposomes.


Price and Availability

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Pricing updated 2020-03-30. Prices are subject to change without notice.

L 644257 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596574
Name: L 644257
CAS#: 68354-99-4
Chemical Formula: C39H69NO5S
Exact Mass: 663.4896
Molecular Weight: 664.04
Elemental Analysis: C, 70.54; H, 10.47; N, 2.11; O, 12.05; S, 4.83


Synonym: L 644257; L-644257; L644257; 6-Coham; Nmanchol;

IUPAC/Chemical Name: (2R,3S,4S,5S,6R)-2-(aminomethyl)-6-((6-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)hexyl)thio)tetrahydro-2H-pyran-3,4,5-triol

InChi Key: SQGBPXZJXZCRMK-LFMDNDDKSA-N

InChi Code: InChI=1S/C39H69NO5S/c1-25(2)11-10-12-26(3)30-15-16-31-29-14-13-27-23-28(17-19-38(27,4)32(29)18-20-39(30,31)5)44-21-8-6-7-9-22-46-37-36(43)35(42)34(41)33(24-40)45-37/h13,25-26,28-37,41-43H,6-12,14-24,40H2,1-5H3/t26-,28+,29+,30-,31+,32+,33-,34-,35+,36+,37-,38+,39-/m1/s1

SMILES Code: O[C@@H]([C@H]([C@@H]([C@@H](CN)O1)O)O)[C@H]1SCCCCCCO[C@H]2CC[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]5([H])[C@]4([H])CC=C3C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ponpipom MM, Hagmann WK, O'Grady LA, Jackson JJ, Wood DD, Zweerink HJ. Glycolipids as host resistance stimulators. J Med Chem. 1990 Feb;33(2):861-7. PubMed PMID: 2299649.

2: Hagmann WK, Ponpipom MM, Jackson JJ, Wood DD, Boltz RC Jr, Zweerink HJ. Steroidal glycolipid, L-644,257, is a potent enhancer of nonspecific host resistance. Int J Immunopharmacol. 1990;12(2):241-6. PubMed PMID: 2329016.

3: Schwendener RA, Lagocki PA, Rahman YE. The effects of charge and size on the interaction of unilamellar liposomes with macrophages. Biochim Biophys Acta. 1984 Apr 25;772(1):93-101. PubMed PMID: 6712952.

4: Wu MS, Robbins JC, Bugianesi RL, Ponpipom MM, Shen TY. Modified in vivo behavior of liposomes containing synthetic glycolipids. Biochim Biophys Acta. 1981 Apr 17;674(1):19-29. PubMed PMID: 7236728.