L 636499

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596569

CAS#: 71474-64-1

Description: L 636499 is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-03-30. Prices are subject to change without notice.

L 636499 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 596569
Name: L 636499
CAS#: 71474-64-1
Chemical Formula: C15H10O4S
Exact Mass: 286.03
Molecular Weight: 286.3
Elemental Analysis: C, 62.93; H, 3.52; O, 22.35; S, 11.20


Synonym: L 636499; L-636499; L636499;

IUPAC/Chemical Name: dibenzo[b,f]thiepine-3-carboxylic acid 5,5-dioxide

InChi Key: ASJSKZXRWOAFGL-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10O4S/c16-15(17)12-8-7-11-6-5-10-3-1-2-4-13(10)20(18,19)14(11)9-12/h1-9H,(H,16,17)

SMILES Code: O=C(C1=CC=C(C=CC2=CC=CC=C23)C(S3(=O)=O)=C1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Siegfried ME, Bush LR. Dual antagonism by L-636,499 of serotonin and thromboxane A2 induced aggregation of canine platelets. Thromb Res. 1990 Dec 1;60(5):343-53. PubMed PMID: 2084956.

2: Hedlund H, Andersson KE, Fovaeus M, Holmquist F, Uski T. Characterization of contraction-mediating prostanoid receptors in human penile erectile tissues. J Urol. 1989 Jan;141(1):182-6. PubMed PMID: 2521189.

3: Liel N, Mais DE, Halushka PV. Desensitization of platelet thromboxane A2/prostaglandin H2 receptors by the mimetic U46619. J Pharmacol Exp Ther. 1988 Dec;247(3):1133-8. PubMed PMID: 2974487.

4: Fitzgerald DJ, Fragetta J, FitzGerald GA. Prostaglandin endoperoxides modulate the response to thromboxane synthase inhibition during coronary thrombosis. J Clin Invest. 1988 Nov;82(5):1708-13. PubMed PMID: 3183064; PubMed Central PMCID: PMC442741.

5: Swayne GT, Maguire J, Dolan J, Raval P, Dane G, Greener M, Owen DA. Evidence for homogeneity of thromboxane A2 receptor using structurally different antagonists. Eur J Pharmacol. 1988 Aug 2;152(3):311-9. PubMed PMID: 2975605.

6: Vargaftig B, Joseph D, Hatmi M. Interference of the thromboxane antagonist SK&F 88046 with platelet activation and subsequent desensitization by arachidonic acid and the thromboxane mimetics U46619 and EP171. Thromb Res. 1987 May 15;46(4):509-17. PubMed PMID: 3039684.

7: Fitzgerald DJ, Fragetta J, Fenelon LC, FitzGerald GA. Thromboxane synthase inhibition and thromboxane/endoperoxide receptor antagonism in a chronic canine model of coronary thrombosis. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:496-500. PubMed PMID: 2959103.

8: Uski TK, Andersson KE. Effects of the thromboxane-receptor antagonist L-636,499 on feline cerebral arteries. Acta Physiol Scand. 1986 Dec;128(4):605-11. PubMed PMID: 2949488.

9: Fitzgerald DJ, Doran J, Jackson E, FitzGerald GA. Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo. J Clin Invest. 1986 Feb;77(2):496-502. PubMed PMID: 3003161; PubMed Central PMCID: PMC423371.

10: Foegh ML, Alijani MR, Helfrich GB, Khirabadi BS, Ramwell PW. Prolongation of cardiac allograft survival with the PAF antagonist BN-52021 and the thromboxane receptor antagonists L640035 and L636499. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:381-4. PubMed PMID: 2936126.