L 368935

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MedKoo CAT#: 596537

CAS#: 145878-31-5

Description: L 368935 is a cholecystokinin receptor antagonist.


Price and Availability

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Pricing updated 2020-03-30. Prices are subject to change without notice.

L 368935 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596537
Name: L 368935
CAS#: 145878-31-5
Chemical Formula: C27H26N8O2
Exact Mass: 494.2179
Molecular Weight: 494.55
Elemental Analysis: C, 65.57; H, 5.30; N, 22.66; O, 6.47


Synonym: L 368935; L-368935; L368935; L-368,935; L 368,935; L368,935;

IUPAC/Chemical Name: (R)-1-(3-(1H-tetrazol-5-yl)phenyl)-3-(1-isobutyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea

InChi Key: WOEBZQREQISGPC-VWLOTQADSA-N

InChi Code: InChI=1S/C27H26N8O2/c1-17(2)16-35-22-14-7-6-13-21(22)23(18-9-4-3-5-10-18)29-25(26(35)36)30-27(37)28-20-12-8-11-19(15-20)24-31-33-34-32-24/h3-15,17,25H,16H2,1-2H3,(H2,28,30,37)(H,31,32,33,34)/t25-/m0/s1

SMILES Code: O=C(NC1=CC=CC(C2=NN=NN2)=C1)N[C@H]3C(N(CC(C)C)C4=CC=CC=C4C(C5=CC=CC=C5)=N3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Patel S, Chapman KL, Smith AJ, Heald A, Freedman SB. Use of ex vivo binding to estimate brain penetration and central activity of CCK-B antagonists. Ann N Y Acad Sci. 1994 Mar 23;713:360-3. PubMed PMID: 8185188.

2: Pedersen K, Nielsen FC, Rehfeld JF. Regulation of the human cholecystokinin gene. Ann N Y Acad Sci. 1994 Mar 23;713:321-3. PubMed PMID: 8185176.

3: Patel S, Chapman KL, Heald A, Smith AJ, Freedman SB. Measurement of central nervous system activity of systemically administered CCKB receptor antagonists by ex vivo binding. Eur J Pharmacol. 1994 Mar 3;253(3):237-44. PubMed PMID: 8200418.