L 364918

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596531

CAS#: 122211-31-8

Description: L 364918 is an oxytocin antagonist; synthetic derivative of L 156373.


Price and Availability

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L 364918 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596531
Name: L 364918
CAS#: 122211-31-8
Chemical Formula: C40H54N8O6
Exact Mass: 742.4166
Molecular Weight: 742.92
Elemental Analysis: C, 64.67; H, 7.33; N, 15.08; O, 12.92


Synonym: L 364918; L-364918; L364918; L 364,918; L-364,918; L364,918;

IUPAC/Chemical Name: (2S)-N-(L-alloisoleucyl)-N-((R)-1-cyclohexyl-3-oxopropan-2-yl)-1-((2R)-3-(3,3-di(pyridazine-3-carbonyl)cyclohexyl)-2-(methylamino)propanoyl)-2,3-dihydro-1H-pyrrole-2-carboxamide

InChi Key: RDHWFPFSGVZZKM-URWURDDHSA-N

InChi Code: InChI=1S/C40H54N8O6/c1-4-26(2)34(41)39(54)48(29(25-49)22-27-12-6-5-7-13-27)38(53)33-17-11-21-47(33)37(52)32(42-3)23-28-14-8-18-40(24-28,35(50)30-15-9-19-43-45-30)36(51)31-16-10-20-44-46-31/h9-11,15-16,19-21,25-29,32-34,42H,4-8,12-14,17-18,22-24,41H2,1-3H3/t26-,28?,29-,32-,33+,34+/m1/s1

SMILES Code: CC[C@H]([C@H](N)C(N(C([C@@H]1CC=CN1C([C@H](NC)CC2CCCC(C(c3nnccc3)=O)(C(c4nnccc4)=O)C2)=O)=O)[C@@H](C=O)CC5CCCCC5)=O)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shimazoe T, Fukumoto T, Shuto T, Watanabe S. [Role of cholecystokinin receptor in methamphetamine-induced reverse tolerance]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Oct;22(5):207. Japanese. PubMed PMID: 12451697.

2: Pettibone DJ, Clineschmidt BV, Anderson PS, Freidinger RM, Lundell GF, Koupal LR, Schwartz CD, Williamson JM, Goetz MA, Hensens OD, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. PubMed PMID: 2544402.