L 365209

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596530

CAS#: 122211-30-7

Description: L 365209 is an oxytocin antagonist; synthetic derivative of L 156373.


Price and Availability

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L 365209 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596530
Name: L 365209
CAS#: 122211-30-7
Chemical Formula: C40H50N8O6
Exact Mass: 738.3853
Molecular Weight: 738.89
Elemental Analysis: C, 65.02; H, 6.82; N, 15.17; O, 12.99


Synonym: L 365209; L-365209; L365209; L 365,209; L-365,209; L365,209;

IUPAC/Chemical Name: 16,24-dibenzyl-13-(sec-butyl)-25-methyl-1,7,8,13,14,16,17,18a,19,20,21,24,25,26a-tetradecahydro-2H,12H-dipyridazino[1,6-a:1',6'-d]pyrrolo[1,2-j][1,4,7,10,13,16]hexaazacyclooctadecine-6,12,15,18,23,26(6aH)-hexaone

InChi Key: IFHSSGUGRIXWQU-UHFFFAOYSA-N

InChi Code: InChI=1S/C40H50N8O6/c1-4-26(2)34-40(54)48-32(19-12-22-42-48)39(53)47-31(18-11-21-41-47)37(51)45(3)33(25-28-16-9-6-10-17-28)38(52)46-23-13-20-30(46)36(50)43-29(35(49)44-34)24-27-14-7-5-8-15-27/h5-10,14-17,21-22,26,29-34H,4,11-13,18-20,23-25H2,1-3H3,(H,43,50)(H,44,49)

SMILES Code: CCC(C1C(N2C(C(N3C(C(N(C)C(Cc4ccccc4)C(N5CCCC5C(NC(Cc6ccccc6)C(N1)=O)=O)=O)=O)CCC=N3)=O)CCC=N2)=O)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Geenen V, Martens H, Robert F, Vrindts-Gevaert Y, De Groote D, Franchimont P. Immunomodulatory properties of cyclic hexapeptide oxytocin antagonists. Thymus. 1992 Dec;20(4):217-26. PubMed PMID: 1492361.

2: Williams PD, Bock MG, Tung RD, Garsky VM, Perlow DS, Erb JM, Lundell GF, Gould NP, Whitter WL, Hoffman JB, et al. Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product. J Med Chem. 1992 Oct 16;35(21):3905-18. PubMed PMID: 1331448.

3: Pettibone DJ, Clineschmidt BV, Lis EV, Reiss DR, Totaro JA, Woyden CJ, Bock MG, Freidinger RM, Tung RD, Veber DF, et al. In vitro pharmacological profile of a novel structural class of oxytocin antagonists. J Pharmacol Exp Ther. 1991 Jan;256(1):304-8. PubMed PMID: 1988661.

4: Grider JR, Makhlouf GM. Distinct receptors for cholecystokinin and gastrin on muscle cells of stomach and gallbladder. Am J Physiol. 1990 Aug;259(2 Pt 1):G184-90. PubMed PMID: 2382717.

5: Pettibone DJ, Clineschmidt BV, Anderson PS, Freidinger RM, Lundell GF, Koupal LR, Schwartz CD, Williamson JM, Goetz MA, Hensens OD, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. PubMed PMID: 2544402.