Elastatinal | CAS#51798-45-9 | elastase inhibitor

Elastatinal
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596500

CAS#: 51798-45-9

Description: Elastatinal is an elastase inhibitor found in culture filtrates of various species of actinomyces.

Chemical Structure

Elastatinal

CAS# 51798-45-9

Instruction

Theoretical Analysis

MedKoo Cat#: 596500
Name: Elastatinal
CAS#: 51798-45-9
Chemical Formula: C21H36N8O7
Exact Mass: 512.27
Molecular Weight: 512.560
Elemental Analysis: C, 49.21; H, 7.08; N, 21.86; O, 21.85

Price and Availability

Size	Price	Availability
5mg	USD 300	2 weeks
10mg	USD 520	2 weeks
25mg	USD 920	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Elastatinal; EINECS 257-426-7; BRN 0873543; BRN-0873543; BRN0873543;

IUPAC/Chemical Name: (((S)-1-((S)-2-amino-1,4,5,6-tetrahydropyrimidin-4-yl)-2-(((S)-5-amino-1,5-dioxo-1-(((S)-1-oxopropan-2-yl)amino)pentan-2-yl)amino)-2-oxoethyl)carbamoyl)-L-leucine

InChi Key: IJWCGVPEDDQUDE-YGJAXBLXSA-N

InChi Code: InChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

SMILES Code: NC(NCC1)=N[C@@H]1[C@H](NC(N[C@H](C(O)=O)CC(C)C)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 512.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Maxson T, Tietz JI, Hudson GA, Guo XR, Tai HC, Mitchell DA. Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins. J Am Chem Soc. 2016 Nov 23;138(46):15157-15166. Epub 2016 Nov 14. PubMed PMID: 27797509; PubMed Central PMCID: PMC5148692.

2: Barros SC, Martins JA, Marcos JC, Cavaco-Paulo A. Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications. Enzyme Microb Technol. 2012 Feb 10;50(2):107-14. doi: 10.1016/j.enzmictec.2011.10.006. Epub 2011 Nov 7. PubMed PMID: 22226196.

3: Sun T, Zhang S, Ji G. Identification and expression of an elastase homologue in Branchiostoma belcheri with implications to the origin of vertebrate pancreas. Mol Biol Rep. 2010 Oct;37(7):3303-9. doi: 10.1007/s11033-009-9916-5. Epub 2009 Nov 12. PubMed PMID: 19908163.

4: Ferreira GA, Magliano AC, Pral EM, Alfieri SC. Elastase secretion in Acanthamoeba polyphaga. Acta Trop. 2009 Nov;112(2):156-63. doi: 10.1016/j.actatropica.2009.07.015. Epub 2009 Jul 24. PubMed PMID: 19632188.

5: David EB, Guimarães S, Ribolla PE, Coradi ST, Alonso DP. Partial characterization of proteolytic activity in Giardia duodenalis purified proteins. Rev Inst Med Trop Sao Paulo. 2007 Nov-Dec;49(6):385-8. PubMed PMID: 18157406.

6: Okumura Y, Ogawa K, Uchiya K. Characterization and primary structure of elastase inhibitor, AFLEI, from Aspergillus flavus. Nihon Ishinkin Gakkai Zasshi. 2007;48(1):13-8. PubMed PMID: 17287718.

7: Ma DH, Yao JY, Kuo MT, See LC, Lin KY, Chen SC, Chen JK, Chao AS, Wang SF, Lin KK. Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):644-51. PubMed PMID: 17251461.

8: Lim JK, Lu W, Hartley O, DeVico AL. N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant. J Leukoc Biol. 2006 Dec;80(6):1395-404. Epub 2006 Sep 8. PubMed PMID: 16963625.

9: Grano V, Salamino F, Melloni E, Minafra R, Regola E, Diano N, Nicolucci C, Attanasio A, Nappi G, Cotrufo M, Maresca L, De Santo NG, Mita DG. Biotechnological traps for the reduction of inflammation due to cardiopulmonary bypass operations. Biomaterials. 2006 Jul;27(20):3855-62. Epub 2006 Mar 14. PubMed PMID: 16533521.

10: Matsuda E, Abe N, Tamakawa H, Kaneko J, Kamio Y. Gene cloning and molecular characterization of an extracellular poly(L-lactic acid) depolymerase from Amycolatopsis sp. strain K104-1. J Bacteriol. 2005 Nov;187(21):7333-40. PubMed PMID: 16237016; PubMed Central PMCID: PMC1272983.

11: Ahn MY, Hahn BS, Ryu KS, Hwang JS, Kim YS. Purification and characterization of a serine protease (CPM-2) with fibrinolytic activity from the dung beetles. Arch Pharm Res. 2005 Jul;28(7):816-22. PubMed PMID: 16114497.

12: Telang MA, Giri AP, Sainani MN, Gupta VS. Characterization of two midgut proteinases of Helicoverpa armigera and their interaction with proteinase inhibitors. J Insect Physiol. 2005 May;51(5):513-22. PubMed PMID: 15893998.

13: Brammer RD, Bramhall SR, Eggo MC. Endostatin expression in pancreatic tissue is modulated by elastase. Br J Cancer. 2005 Jan 17;92(1):89-93. PubMed PMID: 15545970; PubMed Central PMCID: PMC2361736.

14: Belov GA, Lidsky PV, Mikitas OV, Egger D, Lukyanov KA, Bienz K, Agol VI. Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores. J Virol. 2004 Sep;78(18):10166-77. PubMed PMID: 15331749; PubMed Central PMCID: PMC514989.

15: Grano V, Tasco G, Casadio R, Diano N, Portaccio M, Rossi S, Bencivenga U, Compiani M, De Maio A, Mita DG. Reduction of active elastase concentration by means of immobilized inhibitors: a novel therapeutic approach. Biotechnol Prog. 2004 May-Jun;20(3):968-74. PubMed PMID: 15176906.

16: Ahn MY, Hahn BS, Ryu KS, Kim JW, Kim I, Kim YS. Purification and characterization of a serine protease with fibrinolytic activity from the dung beetles, Catharsius molossus. Thromb Res. 2003;112(5-6):339-47. PubMed PMID: 15041280.

17: Krauland AH, Guggi D, Bernkop-Schnürch A. Oral insulin delivery: the potential of thiolated chitosan-insulin tablets on non-diabetic rats. J Control Release. 2004 Mar 24;95(3):547-55. PubMed PMID: 15023465.

18: Guggi D, Kast CE, Bernkop-Schnürch A. In vivo evaluation of an oral salmon calcitonin-delivery system based on a thiolated chitosan carrier matrix. Pharm Res. 2003 Dec;20(12):1989-94. PubMed PMID: 14725364.

19: Guggi D, Bernkop-Schnürch A. In vitro evaluation of polymeric excipients protecting calcitonin against degradation by intestinal serine proteases. Int J Pharm. 2003 Feb 18;252(1-2):187-96. PubMed PMID: 12550794.

20: Pei Y, Ji Z, Yang X, Lu X, Xia Y. [Purification and characterization of cuticle-degrading protease from entomopathogenic fungus, Metarhizium anisopliae]. Wei Sheng Wu Xue Bao. 2000 Jun;40(3):306-11. Chinese. PubMed PMID: 12548997.

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Elastatinal featured