Lycetamine

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MedKoo CAT#: 596491

CAS#: 60209-20-3

Description: Lycetamine is an antimicrobial (Topical).


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-29. Prices are subject to change without notice.

Lycetamine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596491
Name: Lycetamine
CAS#: 60209-20-3
Chemical Formula: C22H47N3O
Exact Mass: 369.3719
Molecular Weight: 369.63
Elemental Analysis: C, 71.49; H, 12.82; N, 11.37; O, 4.33


Synonym: Lycetamine; P-71; P 71; P71;

IUPAC/Chemical Name: 2,6-diamino-N-hexadecylhexanamide

InChi Key: LWEXAPVESMZHFG-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H47N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17-20-25-22(26)21(24)18-15-16-19-23/h21H,2-20,23-24H2,1H3,(H,25,26)

SMILES Code: O=C(NCCCCCCCCCCCCCCCC)C(N)CCCCN


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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4: Wink CS, Meyer GM, Zapp J, Maurer HH. Lefetamine, a controlled drug and pharmaceutical lead of new designer drugs: synthesis, metabolism, and detectability in urine and human liver preparations using GC-MS, LC-MS(n), and LC-high resolution-MS/MS. Anal Bioanal Chem. 2015 Feb;407(6):1545-57. doi: 10.1007/s00216-014-8414-3. Epub 2015 Jan 11. PubMed PMID: 25577353.

5: Wink CS, Meyer GM, Wissenbach DK, Jacobsen-Bauer A, Meyer MR, Maurer HH. Lefetamine-derived designer drugs N-ethyl-1,2-diphenylethylamine (NEDPA) and N-iso-propyl-1,2-diphenylethylamine (NPDPA): metabolism and detectability in rat urine using GC-MS, LC-MSn and LC-HR-MS/MS. Drug Test Anal. 2014 Oct;6(10):1038-48. doi: 10.1002/dta.1621. Epub 2014 Mar 3. PubMed PMID: 24591097.

6: Carrara M, Zampiron S, Pittarello D, Cima L, Rampa A, Valenti P, Da Re P, Giusti P. Modulation of pharmacological profile of diphenylethane (lefetamine-type) derivatives. Arzneimittelforschung. 1997 Jul;47(7):803-9. PubMed PMID: 9272235.

7: Janiri L, Mannelli P, Persico AM, Serretti A, Tempesta E. Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine. Drug Alcohol Depend. 1994 Oct;36(2):139-45. PubMed PMID: 7851281.

8: Massa S, Di Santo R, Mai A, Artico M, Pantaleoni GC, Giorgi R, Coppolino MF. Pyrrylphenylethanones related to cathinone and lefetamine: synthesis and pharmacological activities. Arch Pharm (Weinheim). 1992 Jul;325(7):403-9. PubMed PMID: 1417455.

9: Janiri L, Persico AM, Tempesta E. Dual effects of lephetamine on spontaneous and evoked neuronal firing in the somatosensory cortex of the rat. Neuropharmacology. 1989 Dec;28(12):1405-10. PubMed PMID: 2575715.

10: Mannelli P, Janiri L, De Marinis M, Tempesta E. Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity. Drug Alcohol Depend. 1989 Oct;24(2):95-101. PubMed PMID: 2571492.

11: Massa S, Stefancich G, Artico M, Corelli F, Silvestri R, Pantaleoni GC, Fanini D, Palumbo G, Giorgi R. Synthesis, neuropsychopharmacological effects and analgesic-antiinflammatory activities of pyrrole analogues of lefetamine. Farmaco. 1989 Sep;44(9):763-77. PubMed PMID: 2604832.

12: Janiri L, Mannelli P, Pirrongelli C, Lo Monaco M, Tempesta E. Lephetamine abuse and dependence: clinical effects and withdrawal syndrome. Br J Addict. 1989 Jan;84(1):89-95. PubMed PMID: 2917208.

13: Cagiano R, De Salvia MA, Tattoli M, Lacomba C, Brunello N, Racagni G, Cuomo V. Behavioural and neurochemical changes produced by lefetamine in two inbred strains of mice. Arch Toxicol Suppl. 1989;13:375-7. PubMed PMID: 2774963.

14: Casali R, Nesi MG, Gentili E, Piscitelli P. [Clinical evaluation of analgesia with lefetamine in thoracic surgery]. Minerva Anestesiol. 1987 Jul-Aug;53(7-8):469-72. Italian. PubMed PMID: 3448523.

15: Fontana P, Buonocore P, Agostinis GC. [A new local anesthetic: 0.6% lephetamine. Continuous subarachnoid nerve block in geriatric surgery. Personal method]. Minerva Anestesiol. 1986 Dec;52(12):447-54. Italian. PubMed PMID: 3601114.

16: Fontana P, Buonocore P, Agostinis GC. [Lefetamine 0.6%: continuous subarachnoid nerve block. Our experience through an infusion pump]. Minerva Anestesiol. 1986 Oct;52(10):339-44. Italian. PubMed PMID: 3561819.

17: De Montis MG, Devoto P, Bucarelli A, Tagliamonte A. Opioid activity of lefetamine. Pharmacol Res Commun. 1985 May;17(5):471-8. PubMed PMID: 2994123.

18: Binda GA, Sartini G, Arlandini A, Bianchini A, D'Ambrosio G. [Lephetamine in the treatment of postoperative pain]. Clin Ter. 1984 Dec 31;111(6):545-7. Italian. PubMed PMID: 6525814.

19: Paroli E, Nencini P, Moscucci M. Clinical and experimental evidence of an opiate-like activity of lefetamine. Pharmacol Res Commun. 1984 Sep;16(9):915-22. PubMed PMID: 6095332.

20: Salvatici A, Fontana P, Buonocore P, Cinquegrani A, Vattolo S. [Lefetamine in the control of post-operative pain in abdominal surgery]. Minerva Anestesiol. 1984 Mar;50(3):107-10. Italian. PubMed PMID: 6462477.