L 1935

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596406

CAS#: 13957-35-2

Description: L 1935 is a powerful histamine-liberator.


Price and Availability

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Price

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L 1935 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596406
Name: L 1935
CAS#: 13957-35-2
Chemical Formula: C17H21NO2
Exact Mass: 271.1572
Molecular Weight: 271.36
Elemental Analysis: C, 75.25; H, 7.80; N, 5.16; O, 11.79


Synonym: L 1935; Histamine-liberator L 1935; Compound l1935; L-1935; L1935;

IUPAC/Chemical Name: 4-(3-amino-1-(4-hydroxyphenyl)butyl)-2-methylphenol

InChi Key: QQXUACLYCIWJIU-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H21NO2/c1-11-9-14(5-8-17(11)20)16(10-12(2)18)13-3-6-15(19)7-4-13/h3-9,12,16,19-20H,10,18H2,1-2H3

SMILES Code: OC1=CC=C(C(C2=CC=C(O)C=C2)CC(N)C)C=C1C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kumar GC, Bhuvana K, Venkatarathnamma PN, Sarala N. Serum creatine phosphokinase as predictor of intermediate syndrome in organophosphorus poisoning. Indian J Crit Care Med. 2015 Jul;19(7):384-7. doi: 10.4103/0972-5229.160274. PubMed PMID: 26180430; PubMed Central PMCID: PMC4502490.

2: Gill SJ, Robert CH, Coletta M, Di Cera E, Brunori M. Cooperative free energies for nested allosteric models as applied to human hemoglobin. Biophys J. 1986 Oct;50(4):747-52. PubMed PMID: 3779009; PubMed Central PMCID: PMC1329852.

3: Lecomte J. [Respective role of endogenous histamine and 5-hydroxytryptamine in vascular collapse induced in rats by L 1935]. C R Seances Soc Biol Fil. 1966;160(6):1343-6. French. PubMed PMID: 4381696.

4: RADERMECKER M. [THE INFLUENCE OF AN INHIBITOR OF HISTIDINE DECARBOXYLASE ON HISTAMINE LIBERATION PRODUCED IN MAN BY THE INTRADERMAL INJECTION OF L 1935 AND THE LOCAL ANAPHYLACTIC REACTION]. Acta Allergol. 1965;20:77-83. French. PubMed PMID: 14311532.

5: LECOMTE J, MELON J, PETIT JM. [L 1935, a powerful histamine-liberator, is shown to be without effect on human broncho-pulmonary tissues]. Rev Belg Pathol Med Exp. 1960 Oct;27:212-8. French. PubMed PMID: 13760118.

6: BRANELLEC A, BRIOT M, HALPERN BN, LIACOPOULOS P, NEVEU T. [Histamine-liberating properties of a substituted butylamine (L 1935) in dogs]. C R Seances Soc Biol Fil. 1956;150(7):1302-6. French. PubMed PMID: 13397054.

7: FELDBERG W, LECOMTE J. Release of histamine by a substituted butylamine (L 1935): comparison with compound 48/80. Br J Pharmacol Chemother. 1955 Jun;10(2):254-9. PubMed PMID: 14389669; PubMed Central PMCID: PMC1509492.