WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596386
CAS#: 35175-14-5
Description: L 12407 is an antiprotozoal drug of the nitroimidazole class used in veterinary medicine. It is used for the treatment of histomoniasis in turkeys and for swine dysentery.
MedKoo Cat#: 596386
Name: L 12407
CAS#: 35175-14-5
Chemical Formula: C7H11N3O3
Exact Mass: 185.08
Molecular Weight: 185.183
Elemental Analysis: C, 45.40; H, 5.99; N, 22.69; O, 25.92
Synonym: L 12407; L-12407; L12407; Ipronidazole-OH;
IUPAC/Chemical Name: 2-(1-methyl-5-nitro-1H-imidazol-2-yl)propan-2-ol
InChi Key: DTHPMNDYKOSVFR-UHFFFAOYSA-N
InChi Code: InChI=1S/C7H11N3O3/c1-7(2,11)6-8-4-5(9(6)3)10(12)13/h4,11H,1-3H3
SMILES Code: OC(C)(C)C1=NC=C([N+]([O-])=O)N1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
The following data is based on the product molecular weight 185.183 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
1: Lin Z, Zhen Z, Chen C, Li Y, Luo C, Zhong L, Hu H, Li J, Zhang Y, Liang Y, Yang J, Zhang D. Rhizospheric effects on atrazine speciation and degradation in laterite soils of Pennisetum alopecuroides (L.) Spreng. Environ Sci Pollut Res Int. 2018 May;25(13):12407-12418. doi: 10.1007/s11356-018-1468-6. Epub 2018 Feb 19. PubMed PMID: 29460244.
2: Chen J, Qian Y, Li H, Cheng Y, Zhao M. The reduced bioavailability of copper by nano-TiO₂ attenuates the toxicity to Microcystis aeruginosa. Environ Sci Pollut Res Int. 2015 Aug;22(16):12407-14. doi: 10.1007/s11356-015-4492-9. Epub 2015 Apr 23. PubMed PMID: 25903177.
3: Das LK, Kadam RM, Bauzá A, Frontera A, Ghosh A. Differences in nuclearity, molecular shapes, and coordination modes of azide in the complexes of Cd(II) and Hg(II) with a "metalloligand" [CuL] (H2L = N,N'-bis(salicylidene)-1,3-propanediamine): characterization in solid and in solutions, and theoretical calculations. Inorg Chem. 2012 Nov 19;51(22):12407-18. doi: 10.1021/ic301773h. Epub 2012 Nov 6. PubMed PMID: 23131113.
4: Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, Thakker DR. Direct activation of human phospholipase C by its well known inhibitor u73122. J Biol Chem. 2011 Apr 8;286(14):12407-16. doi: 10.1074/jbc.M110.191783. Epub 2011 Jan 25. PubMed PMID: 21266572; PubMed Central PMCID: PMC3069444.
