JWH-307

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596375

CAS#: 914458-26-7

Description: JWH 307 is discontinued (DEA controlled substance). It is a (1-naphthoyl)pyrrole cannabimimetic that potently activates both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors . Its physiological, neurological, and toxicological properties have not been evaluated.


Chemical Structure

img
JWH-307
CAS# 914458-26-7

Theoretical Analysis

MedKoo Cat#: 596375
Name: JWH-307
CAS#: 914458-26-7
Chemical Formula: C26H24FNO
Exact Mass: 385.1842
Molecular Weight: 385.48
Elemental Analysis: C, 81.01; H, 6.28; F, 4.93; N, 3.63; O, 4.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JWH-307; JWH 307; JWH307;

IUPAC/Chemical Name: (5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone

InChi Key: WYNZPDDTQGVCLZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H24FNO/c1-2-3-8-16-28-18-20(17-25(28)23-13-6-7-15-24(23)27)26(29)22-14-9-11-19-10-4-5-12-21(19)22/h4-7,9-15,17-18H,2-3,8,16H2,1H3

SMILES Code: O=C(C1=CN(CCCCC)C(C2=CC=CC=C2F)=C1)C3=C4C=CC=CC4=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 385.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hutter M, Broecker S, Kneisel S, Franz F, Brandt SD, Auwarter V. Metabolism of Synthetic Cannabinoid Receptor Agonists Encountered in Clinical Casework: Major in vivo Phase I Metabolites of JWH-007, JWH-019, JWH-203, JWH-307, UR-144, XLR-11, AM-2201, MAM-2201 and AM-694 in Human Urine Using LC-MS/MS. Curr Pharm Biotechnol. 2018 May 9. doi: 10.2174/1389201019666180509163114. [Epub ahead of print] PubMed PMID: 29745330.

2: Göl E, Çok İ. Assessment of types of synthetic cannabinoids in narcotic cases assessed by the Council of Forensic Medicine between 2011-2015, Ankara, Turkey. Forensic Sci Int. 2017 Nov;280:124-129. doi: 10.1016/j.forsciint.2017.09.017. Epub 2017 Oct 4. PubMed PMID: 29028489.

3: Strano-Rossi S, Anzillotti L, Dragoni S, Pellegrino RM, Goracci L, Pascali VL, Cruciani G. Metabolism of JWH-015, JWH-098, JWH-251, and JWH-307 in silico and in vitro: a pilot study for the detection of unknown synthetic cannabinoids metabolites. Anal Bioanal Chem. 2014 Jun;406(15):3621-36. doi: 10.1007/s00216-014-7793-9. Epub 2014 May 8. PubMed PMID: 24804821.

4: Musshoff F, Madea B, Kernbach-Wighton G, Bicker W, Kneisel S, Hutter M, Auwärter V. Driving under the influence of synthetic cannabinoids ("Spice"): a case series. Int J Legal Med. 2014 Jan;128(1):59-64. doi: 10.1007/s00414-013-0864-1. Epub 2013 May 1. PubMed PMID: 23636569.

5: Kneisel S, Auwärter V, Kempf J. Analysis of 30 synthetic cannabinoids in oral fluid using liquid chromatography-electrospray ionization tandem mass spectrometry. Drug Test Anal. 2013 Aug;5(8):657-69. doi: 10.1002/dta.1429. Epub 2012 Oct 18. PubMed PMID: 23081933.

6: Uchiyama N, Kawamura M, Kikura-Hanajiri R, Goda Y. URB-754: a new class of designer drug and 12 synthetic cannabinoids detected in illegal products. Forensic Sci Int. 2013 Apr 10;227(1-3):21-32. doi: 10.1016/j.forsciint.2012.08.047. Epub 2012 Oct 9. PubMed PMID: 23063179.

7: Kneisel S, Auwärter V. Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction. J Mass Spectrom. 2012 Jul;47(7):825-35. doi: 10.1002/jms.3020. PubMed PMID: 22791249.

8: Ernst L, Krüger K, Lindigkeit R, Schiebel HM, Beuerle T. Synthetic cannabinoids in "spice-like" herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German market. Forensic Sci Int. 2012 Oct 10;222(1-3):216-22. doi: 10.1016/j.forsciint.2012.05.027. Epub 2012 Jun 28. PubMed PMID: 22748479.