JWH-203

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596373

CAS#: 864445-54-5

Description: JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid (CB) agonist with Ki values of 8.0 and 7.0 nM at the CB1 and CB2 receptors, respectively. JWH-203 is discontinued (DEA controlled substance).


Chemical Structure

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JWH-203
CAS# 864445-54-5

Theoretical Analysis

MedKoo Cat#: 596373
Name: JWH-203
CAS#: 864445-54-5
Chemical Formula: C21H22ClNO
Exact Mass: 339.139
Molecular Weight: 339.86
Elemental Analysis: C, 74.22; H, 6.52; Cl, 10.43; N, 4.12; O, 4.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JWH-203; JWH 203; JWH203

IUPAC/Chemical Name: 2-(2-chlorophenyl)-1-(1-pentyl-1H-indol-3-yl)ethan-1-one

InChi Key: YDINKDBAZJOSLV-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22ClNO/c1-2-3-8-13-23-15-18(17-10-5-7-12-20(17)23)21(24)14-16-9-4-6-11-19(16)22/h4-7,9-12,15H,2-3,8,13-14H2,1H3

SMILES Code: O=C(C1=CN(CCCCC)C2=C1C=CC=C2)CC3=CC=CC=C3Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 339.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hutter M, Broecker S, Kneisel S, Franz F, Brandt SD, Auwarter V. Metabolism of Synthetic Cannabinoid Receptor Agonists Encountered in Clinical Casework: Major in vivo Phase I Metabolites of JWH-007, JWH-019, JWH-203, JWH-307, UR-144, XLR-11, AM-2201, MAM-2201 and AM-694 in Human Urine Using LC-MS/MS. Curr Pharm Biotechnol. 2018 May 9. doi: 10.2174/1389201019666180509163114. [Epub ahead of print] PubMed PMID: 29745330.

2: Gatch MB, Forster MJ. Δ9-Tetrahydrocannabinol-like discriminative stimulus effects of compounds commonly found in K2/Spice. Behav Pharmacol. 2014 Dec;25(8):750-7. doi: 10.1097/FBP.0000000000000093. PubMed PMID: 25325289; PubMed Central PMCID: PMC4216610.

3: Simões SS, Silva I, Ajenjo AC, Dias MJ. Validation and application of an UPLC-MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market. Forensic Sci Int. 2014 Oct;243:117-25. doi: 10.1016/j.forsciint.2014.07.022. Epub 2014 Jul 27. PubMed PMID: 25127518.

4: Sysoev AA, Poteshin SS, Chernyshev DM, Karpov AV, Tuzkov YB, Kyzmin VV, Sysoev AA. Analysis of new synthetic drugs by ion mobility time-of-flight mass spectrometry. Eur J Mass Spectrom (Chichester). 2014;20(2):185-92. PubMed PMID: 24895779.

5: Haro G, Ripoll C, Ibáñez M, Orengo T, Liaño VM, Meneu E, Hernández F, Traver F. Could spice drugs induce psychosis with abnormal movements similar to catatonia? Psychiatry. 2014 Summer;77(2):206-8. doi: 10.1521/psyc.2014.77.2.206. PubMed PMID: 24865202.

6: Scheidweiler KB, Huestis MA. Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2014 Jan 31;1327:105-17. doi: 10.1016/j.chroma.2013.12.067. Epub 2013 Dec 30. PubMed PMID: 24418231; PubMed Central PMCID: PMC3963402.

7: Lesiak AD, Musah RA, Domin MA, Shepard JR. DART-MS as a preliminary screening method for "herbal incense": chemical analysis of synthetic cannabinoids. J Forensic Sci. 2014 Mar;59(2):337-43. doi: 10.1111/1556-4029.12354. Epub 2013 Dec 6. PubMed PMID: 24313746.

8: Kavanagh P, Grigoryev A, Melnik A, Savchuk S, Simonov A, Rozhanets V. Detection and tentative identification of urinary phase I metabolites of phenylacetylindole cannabimimetics JWH-203 and JWH-251, by GC-MS and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:102-8. doi: 10.1016/j.jchromb.2013.07.005. Epub 2013 Jul 15. PubMed PMID: 23917406.

9: Ibáñez M, Bijlsma L, van Nuijs AL, Sancho JV, Haro G, Covaci A, Hernández F. Quadrupole-time-of-flight mass spectrometry screening for synthetic cannabinoids in herbal blends. J Mass Spectrom. 2013 Jun;48(6):685-94. doi: 10.1002/jms.3217. PubMed PMID: 23722959.

10: Denooz R, Vanheugen JC, Frederich M, de Tullio P, Charlier C. Identification and structural elucidation of four cannabimimetic compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in seized products. J Anal Toxicol. 2013 Mar;37(2):56-63. doi: 10.1093/jat/bks095. Epub 2013 Jan 20. PubMed PMID: 23339188.

11: Kneisel S, Auwärter V, Kempf J. Analysis of 30 synthetic cannabinoids in oral fluid using liquid chromatography-electrospray ionization tandem mass spectrometry. Drug Test Anal. 2013 Aug;5(8):657-69. doi: 10.1002/dta.1429. Epub 2012 Oct 18. PubMed PMID: 23081933.

12: Musah RA, Domin MA, Cody RB, Lesiak AD, Dane AJ, Shepard JR. Direct analysis in real time mass spectrometry with collision-induced dissociation for structural analysis of synthetic cannabinoids. Rapid Commun Mass Spectrom. 2012 Oct 15;26(19):2335-42. doi: 10.1002/rcm.6354. PubMed PMID: 22956326.

13: Hutter M, Kneisel S, Auwärter V, Neukamm MA. Determination of 22 synthetic cannabinoids in human hair by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:95-101. doi: 10.1016/j.jchromb.2012.07.002. Epub 2012 Jul 17. PubMed PMID: 22835826.

14: Kneisel S, Auwärter V. Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction. J Mass Spectrom. 2012 Jul;47(7):825-35. doi: 10.1002/jms.3020. PubMed PMID: 22791249.

15: Simolka K, Lindigkeit R, Schiebel HM, Papke U, Ernst L, Beuerle T. Analysis of synthetic cannabinoids in "spice-like" herbal highs: snapshot of the German market in summer 2011. Anal Bioanal Chem. 2012 Jul;404(1):157-71. doi: 10.1007/s00216-012-6122-4. Epub 2012 Jun 19. PubMed PMID: 22710567.

16: Bononi M, Belgi P, Tateo F. Analytical data for identification of the Cannabimimetic Phenylacetylindole JWH-203. J Anal Toxicol. 2011 Jul;35(6):360-3. PubMed PMID: 21740693.