JWH-251

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596371

CAS#: 864445-39-6

Description: JWH 251 is discontinued (DEA controlled substance). This product is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM). JWH 251 stimulates GTPγS binding of CB1 and CB2 receptors with EC50 values of 29 and 8.3 nM, respectively.


Chemical Structure

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JWH-251
CAS# 864445-39-6

Theoretical Analysis

MedKoo Cat#: 596371
Name: JWH-251
CAS#: 864445-39-6
Chemical Formula: C22H25NO
Exact Mass: 319.1936
Molecular Weight: 319.44
Elemental Analysis: C, 82.72; H, 7.89; N, 4.38; O, 5.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JWH-251; JWH 251; JWH251;

IUPAC/Chemical Name: 1-(1-pentyl-1H-indol-3-yl)-2-(o-tolyl)ethan-1-one

InChi Key: YBIPNGRKUAVSBG-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H25NO/c1-3-4-9-14-23-16-20(19-12-7-8-13-21(19)23)22(24)15-18-11-6-5-10-17(18)2/h5-8,10-13,16H,3-4,9,14-15H2,1-2H3

SMILES Code: O=C(C1=CN(CCCCC)C2=C1C=CC=C2)CC3=CC=CC=C3C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 319.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Göl E, Çok İ. Assessment of types of synthetic cannabinoids in narcotic cases assessed by the Council of Forensic Medicine between 2011-2015, Ankara, Turkey. Forensic Sci Int. 2017 Nov;280:124-129. doi: 10.1016/j.forsciint.2017.09.017. Epub 2017 Oct 4. PubMed PMID: 29028489.

2: Strano-Rossi S, Anzillotti L, Dragoni S, Pellegrino RM, Goracci L, Pascali VL, Cruciani G. Metabolism of JWH-015, JWH-098, JWH-251, and JWH-307 in silico and in vitro: a pilot study for the detection of unknown synthetic cannabinoids metabolites. Anal Bioanal Chem. 2014 Jun;406(15):3621-36. doi: 10.1007/s00216-014-7793-9. Epub 2014 May 8. PubMed PMID: 24804821.

3: Kavanagh P, Grigoryev A, Melnik A, Savchuk S, Simonov A, Rozhanets V. Detection and tentative identification of urinary phase I metabolites of phenylacetylindole cannabimimetics JWH-203 and JWH-251, by GC-MS and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:102-8. doi: 10.1016/j.jchromb.2013.07.005. Epub 2013 Jul 15. PubMed PMID: 23917406.

4: Hutter M, Kneisel S, Auwärter V, Neukamm MA. Determination of 22 synthetic cannabinoids in human hair by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:95-101. doi: 10.1016/j.jchromb.2012.07.002. Epub 2012 Jul 17. PubMed PMID: 22835826.

5: Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. PubMed PMID: 16005223.