JWH-122

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596364

CAS#: 619294-47-2

Description: JWH 122 is a synthetic cannabinoid (CB) that displays high-affinities for both CB1 and CB2 receptors. JWH-122 is discontinued (DEA controlled substance).


Chemical Structure

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JWH-122
CAS# 619294-47-2

Theoretical Analysis

MedKoo Cat#: 596364
Name: JWH-122
CAS#: 619294-47-2
Chemical Formula: C25H25NO
Exact Mass: 355.1936
Molecular Weight: 355.48
Elemental Analysis: C, 84.47; H, 7.09; N, 3.94; O, 4.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JWH-122; JWH 122; JWH122

IUPAC/Chemical Name: (4-methylnaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone

InChi Key: HUKJQMKQFWYIHS-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H25NO/c1-3-4-9-16-26-17-23(21-12-7-8-13-24(21)26)25(27)22-15-14-18(2)19-10-5-6-11-20(19)22/h5-8,10-15,17H,3-4,9,16H2,1-2H3

SMILES Code: O=C(C1=C2C=CC=CC2=C(C)C=C1)C3=CN(CCCCC)C4=C3C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 355.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Costain WJ, Rasquinha I, Comas T, Hewitt M, Aylsworth A, Rouleau Y, Marleau V, Soo EC, Tauskela JS. Analysis of the pharmacological properties of JWH-122 isomers and THJ-2201, RCS-4 and AB-CHMINACA in HEK293T cells and hippocampal neurons. Eur J Pharmacol. 2018 Mar 15;823:96-104. doi: 10.1016/j.ejphar.2018.01.043. Epub 2018 Feb 4. PubMed PMID: 29408093.

2: Paul ABM, Simms L, Amini S, Paul AE. Teens and Spice: A Review of Adolescent Fatalities Associated with Synthetic Cannabinoid Use. J Forensic Sci. 2017 Dec 1. doi: 10.1111/1556-4029.13704. [Epub ahead of print] PubMed PMID: 29194599.

3: Göl E, Çok İ. Assessment of types of synthetic cannabinoids in narcotic cases assessed by the Council of Forensic Medicine between 2011-2015, Ankara, Turkey. Forensic Sci Int. 2017 Nov;280:124-129. doi: 10.1016/j.forsciint.2017.09.017. Epub 2017 Oct 4. PubMed PMID: 29028489.

4: Assemat G, Dubocq F, Balayssac S, Lamoureux C, Malet-Martino M, Gilard V. Screening of "spice" herbal mixtures: From high-field to low-field proton NMR. Forensic Sci Int. 2017 Oct;279:88-95. doi: 10.1016/j.forsciint.2017.08.006. Epub 2017 Aug 12. PubMed PMID: 28854352.

5: Moore KN, Garvin D, Thomas BF, Grabenauer M. Identification of Eight Synthetic Cannabinoids, Including 5F-AKB48 in Seized Herbal Products Using DART-TOF-MS and LC-QTOF-MS as Nontargeted Screening Methods. J Forensic Sci. 2017 Sep;62(5):1151-1158. doi: 10.1111/1556-4029.13367. Epub 2017 Jun 9. PubMed PMID: 28597943.

6: Hruba L, McMahon LR. Apparent Affinity Estimates and Reversal of the Effects of Synthetic Cannabinoids AM-2201, CP-47,497, JWH-122, and JWH-250 by Rimonabant in Rhesus Monkeys. J Pharmacol Exp Ther. 2017 Aug;362(2):278-286. doi: 10.1124/jpet.117.240572. Epub 2017 May 22. PubMed PMID: 28533288; PubMed Central PMCID: PMC5502382.

7: Coppola M, Mondola R. JWH-122 Consumption Adverse Effects: A Case of Hallucinogen Persisting Perception Disorder Five-Year Follow-Up. J Psychoactive Drugs. 2017 Jul-Aug;49(3):262-265. doi: 10.1080/02791072.2017.1316431. Epub 2017 Apr 25. PubMed PMID: 28441106.

8: Cannaert A, Storme J, Franz F, Auwärter V, Stove CP. Detection and Activity Profiling of Synthetic Cannabinoids and Their Metabolites with a Newly Developed Bioassay. Anal Chem. 2016 Dec 6;88(23):11476-11485. Epub 2016 Nov 7. PubMed PMID: 27779402.

9: Rácz N, Veress T, Nagy J, Bobály B, Fekete J. Separation of Isomers of JWH-122 on Porous Graphitic Carbon Stationary Phase with Non-Aqueous Mobile Phase Using Intelligent Software. J Chromatogr Sci. 2016 Nov;54(10):1735-1742. Epub 2016 Sep 27. PubMed PMID: 27681775.

10: Tynon M, Homan J, Kacinko S, Ervin A, McMullin M, Logan BK. Rapid and sensitive screening and confirmation of thirty-four aminocarbonyl/carboxamide (NACA) and arylindole synthetic cannabinoid drugs in human whole blood. Drug Test Anal. 2017 Jun;9(6):924-934. doi: 10.1002/dta.2096. Epub 2016 Oct 13. PubMed PMID: 27653946.

11: Kill JB, Oliveira IF, Tose LV, Costa HB, Kuster RM, Machado LF, Correia RM, Rodrigues RRT, Vasconcellos GA, Vaz BG, Romão W. Chemical characterization of synthetic cannabinoids by electrospray ionization FT-ICR mass spectrometry. Forensic Sci Int. 2016 Sep;266:474-487. doi: 10.1016/j.forsciint.2016.07.007. Epub 2016 Jul 19. PubMed PMID: 27471991.

12: Gatch MB, Forster MJ. Δ(9)-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids in mice and rats. Psychopharmacology (Berl). 2016 May;233(10):1901-10. doi: 10.1007/s00213-016-4237-6. Epub 2016 Feb 15. PubMed PMID: 26875756; PubMed Central PMCID: PMC4846470.

13: Smoluch M, Gierczyk B, Reszke E, Babij M, Gotszalk T, Schroeder G, Silberring J. FAPA mass spectrometry of designer drugs. Talanta. 2016;146:29-33. doi: 10.1016/j.talanta.2015.07.094. Epub 2015 Aug 3. PubMed PMID: 26695230.

14: Borova VL, Gago-Ferrero P, Pistos C, Thomaidis NS. Multi-residue determination of 10 selected new psychoactive substances in wastewater samples by liquid chromatography-tandem mass spectrometry. Talanta. 2015 Nov 1;144:592-603. doi: 10.1016/j.talanta.2015.06.080. Epub 2015 Jul 6. PubMed PMID: 26452866.

15: Hess C, Stockhausen S, Kernbach-Wighton G, Madea B. Death due to diabetic ketoacidosis: Induction by the consumption of synthetic cannabinoids? Forensic Sci Int. 2015 Dec;257:e6-e11. doi: 10.1016/j.forsciint.2015.08.012. Epub 2015 Aug 29. PubMed PMID: 26363623.

16: Berg T, Kaur L, Risnes A, Havig SM, Karinen R. Determination of a selection of synthetic cannabinoids and metabolites in urine by UHPSFC-MS/MS and by UHPLC-MS/MS. Drug Test Anal. 2016 Jul;8(7):708-22. doi: 10.1002/dta.1844. Epub 2015 Aug 25. PubMed PMID: 26304456.

17: Nakamura Y, Nakano M, Nakamura M, Miyazaki D, Okamori S, Akuzawa H, Yuasa M. [Case of law-evading herbs poisoning that induced shock and myocardial damage]. Chudoku Kenkyu. 2014 Dec;27(4):333-8. Japanese. PubMed PMID: 25771668.

18: Uchiyama N, Kikura-Hanajiri R, Hakamatsuka T. [Evaluation of an on-site drug-testing device for the detection of synthetic cannabinoids in illegal herbal products]. Yakugaku Zasshi. 2015;135(3):535-41. doi: 10.1248/yakushi.14-00247. Epub 2015 Jan 19. Japanese. PubMed PMID: 25759062.

19: Karinen R, Tuv SS, Øiestad EL, Vindenes V. Concentrations of APINACA, 5F-APINACA, UR-144 and its degradant product in blood samples from six impaired drivers compared to previous reported concentrations of other synthetic cannabinoids. Forensic Sci Int. 2015 Jan;246:98-103. doi: 10.1016/j.forsciint.2014.11.012. Epub 2014 Nov 21. PubMed PMID: 25485949.

20: Kim J, Park Y, Park M, Kim E, Yang W, Baeck S, Lee S, Han S. Simultaneous determination of five naphthoylindole-based synthetic cannabinoids and metabolites and their deposition in human and rat hair. J Pharm Biomed Anal. 2015 Jan;102:162-75. doi: 10.1016/j.jpba.2014.09.013. Epub 2014 Sep 21. PubMed PMID: 25282599.