JWH-081

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596360

CAS#: 210179-46-7

Description: JWH 081 is an analytical reference standard categorized as a synthetic cannabinoid, It has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 081 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. JWH-081 is discontinued (DEA controlled substance).


Chemical Structure

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JWH-081
CAS# 210179-46-7

Theoretical Analysis

MedKoo Cat#: 596360
Name: JWH-081
CAS#: 210179-46-7
Chemical Formula: C25H25NO2
Exact Mass: 371.1885
Molecular Weight: 371.48
Elemental Analysis: C, 80.83; H, 6.78; N, 3.77; O, 8.61

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JWH-081; JWH-081; JWH-081;

IUPAC/Chemical Name: (4-methoxynaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone

InChi Key: UBMPKJKGUQDHRM-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H25NO2/c1-3-4-9-16-26-17-22(19-11-7-8-13-23(19)26)25(27)21-14-15-24(28-2)20-12-6-5-10-18(20)21/h5-8,10-15,17H,3-4,9,16H2,1-2H3

SMILES Code: O=C(C1=C2C=CC=CC2=C(OC)C=C1)C3=CN(CCCCC)C4=C3C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 371.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Assemat G, Dubocq F, Balayssac S, Lamoureux C, Malet-Martino M, Gilard V. Screening of "spice" herbal mixtures: From high-field to low-field proton NMR. Forensic Sci Int. 2017 Oct;279:88-95. doi: 10.1016/j.forsciint.2017.08.006. Epub 2017 Aug 12. PubMed PMID: 28854352.

2: de la Asunción-Nadal V, Armenta S, Garrigues S, de la Guardia M. Identification and determination of synthetic cannabinoids in herbal products by dry film attenuated total reflectance-infrared spectroscopy. Talanta. 2017 May 15;167:344-351. doi: 10.1016/j.talanta.2017.02.026. Epub 2017 Feb 12. PubMed PMID: 28340730.

3: Tynon M, Homan J, Kacinko S, Ervin A, McMullin M, Logan BK. Rapid and sensitive screening and confirmation of thirty-four aminocarbonyl/carboxamide (NACA) and arylindole synthetic cannabinoid drugs in human whole blood. Drug Test Anal. 2017 Jun;9(6):924-934. doi: 10.1002/dta.2096. Epub 2016 Oct 13. PubMed PMID: 27653946.

4: Kill JB, Oliveira IF, Tose LV, Costa HB, Kuster RM, Machado LF, Correia RM, Rodrigues RRT, Vasconcellos GA, Vaz BG, Romão W. Chemical characterization of synthetic cannabinoids by electrospray ionization FT-ICR mass spectrometry. Forensic Sci Int. 2016 Sep;266:474-487. doi: 10.1016/j.forsciint.2016.07.007. Epub 2016 Jul 19. PubMed PMID: 27471991.

5: Kusano M, Zaitsu K, Yamanaka M, Hisatsune K, Asano T, Taki K, Hayashi Y, Tsuchihashi H, Ishii A. Development of a mass spectrometric hydroxyl-position determination method for the hydroxyindole metabolites of JWH-018 by GC-MS/MS. J Mass Spectrom. 2016 May;51(5):350-7. doi: 10.1002/jms.3761. PubMed PMID: 27194519.

6: Lung D, Wilson N, Chatenet FT, LaCroix C, Gerona R. Non-targeted screening for novel psychoactive substances among agitated emergency department patients. Clin Toxicol (Phila). 2016;54(4):319-23. doi: 10.3109/15563650.2016.1139714. Epub 2016 Feb 5. PubMed PMID: 26846684.

7: Blakey K, Boyd S, Atkinson S, Wolf J, Slottje PM, Goodchild K, McGowan J. Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense. Forensic Sci Int. 2016 Mar;260:40-53. doi: 10.1016/j.forsciint.2015.12.001. Epub 2015 Dec 14. PubMed PMID: 26795397.

8: Cha HJ, Seong YH, Song MJ, Jeong HS, Shin J, Yun J, Han K, Kim YH, Kang H, Kim HS. Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210. Biomol Ther (Seoul). 2015 Nov;23(6):597-603. doi: 10.4062/biomolther.2015.057. Epub 2015 Nov 1. PubMed PMID: 26535086; PubMed Central PMCID: PMC4624077.

9: Kusano M, Zaitsu K, Nakayama H, Nakajima J, Hisatsune K, Moriyasu T, Matsuta S, Katagi M, Tsuchihashi H, Ishii A. Positional isomer differentiation of synthetic cannabinoid JWH-081 by GC-MS/MS. J Mass Spectrom. 2015 Mar;50(3):586-91. doi: 10.1002/jms.3565. PubMed PMID: 25800195.

10: Nakamura Y, Nakano M, Nakamura M, Miyazaki D, Okamori S, Akuzawa H, Yuasa M. [Case of law-evading herbs poisoning that induced shock and myocardial damage]. Chudoku Kenkyu. 2014 Dec;27(4):333-8. Japanese. PubMed PMID: 25771668.

11: Wohlfarth A, Scheidweiler KB, Castaneto M, Gandhi AS, Desrosiers NA, Klette KL, Martin TM, Huestis MA. Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens. Clin Chem Lab Med. 2015 Feb;53(3):423-34. doi: 10.1515/cclm-2014-0612. PubMed PMID: 25263309.

12: Scheidweiler KB, Jarvis MJ, Huestis MA. Nontargeted SWATH acquisition for identifying 47 synthetic cannabinoid metabolites in human urine by liquid chromatography-high-resolution tandem mass spectrometry. Anal Bioanal Chem. 2015 Jan;407(3):883-97. doi: 10.1007/s00216-014-8118-8. Epub 2014 Sep 16. PubMed PMID: 25224637.

13: Maciów-Głąb M, Rojek S, Kula K, Kłys M. "New designer drugs" in aspects of forensic toxicology. Arch Med Sadowej Kryminol. 2014 Jan-Mar;64(1):20-33. PubMed PMID: 25184424.

14: Cha HJ, Lee KW, Song MJ, Hyeon YJ, Hwang JY, Jang CG, Ahn JI, Jeon SH, Kim HU, Kim YH, Seong WK, Kang H, Yoo HS, Jeong HS. Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches. Biomol Ther (Seoul). 2014 Jul;22(4):363-9. doi: 10.4062/biomolther.2014.039. PubMed PMID: 25143817; PubMed Central PMCID: PMC4131522.

15: Haro G, Ripoll C, Ibáñez M, Orengo T, Liaño VM, Meneu E, Hernández F, Traver F. Could spice drugs induce psychosis with abnormal movements similar to catatonia? Psychiatry. 2014 Summer;77(2):206-8. doi: 10.1521/psyc.2014.77.2.206. PubMed PMID: 24865202.

16: Kronstrand R, Brinkhagen L, Birath-Karlsson C, Roman M, Josefsson M. LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine. Anal Bioanal Chem. 2014 Jun;406(15):3599-609. doi: 10.1007/s00216-013-7574-x. Epub 2014 Jan 15. PubMed PMID: 24424965.

17: Scheidweiler KB, Huestis MA. Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2014 Jan 31;1327:105-17. doi: 10.1016/j.chroma.2013.12.067. Epub 2013 Dec 30. PubMed PMID: 24418231; PubMed Central PMCID: PMC3963402.

18: Tuv SS, Krabseth H, Karinen R, Olsen KM, Øiestad EL, Vindenes V. Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period. Accid Anal Prev. 2014 Jan;62:26-31. doi: 10.1016/j.aap.2013.09.009. Epub 2013 Sep 21. PubMed PMID: 24129318.

19: Basavarajappa BS, Subbanna S. CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations. Hippocampus. 2014 Feb;24(2):178-88. PubMed PMID: 24123667; PubMed Central PMCID: PMC3959795.

20: Salomone A, Luciano C, Di Corcia D, Gerace E, Vincenti M. Hair analysis as a tool to evaluate the prevalence of synthetic cannabinoids in different populations of drug consumers. Drug Test Anal. 2014 Jan-Feb;6(1-2):126-34. doi: 10.1002/dta.1556. Epub 2013 Sep 30. PubMed PMID: 24115381.