Lysine-methotrexate
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Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591191

CAS#: 80407-56-3

Description: Lysine-methotrexate is an anticancer drug. It is the lysine analog of methotrexate; inhibitor of dihydrofolate reductase.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 320 2 Weeks
10mg USD 550 2 Weeks
25mg USD 1040 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-29. Prices are subject to change without notice.

Lysine-methotrexate purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 200mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 591191
Name: Lysine-methotrexate
CAS#: 80407-56-3
Chemical Formula: C21H27N9O3
Exact Mass: 453.2237
Molecular Weight: 453.51
Elemental Analysis: C, 55.62; H, 6.00; N, 27.80; O, 10.58


Synonym: Lysine-methotrexate; ADMPL;

IUPAC/Chemical Name: L-Lysine, N2-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-

InChi Key: XERJQLWAFDLUGV-HNNXBMFYSA-N

InChi Code: InChI=1S/C21H27N9O3/c1-30(11-13-10-25-18-16(26-13)17(23)28-21(24)29-18)14-7-5-12(6-8-14)19(31)27-15(20(32)33)4-2-3-9-22/h5-8,10,15H,2-4,9,11,22H2,1H3,(H,27,31)(H,32,33)(H4,23,24,25,28,29)/t15-/m0/s1

SMILES Code: NCCCC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Singh VK, Subudhi BB. Development and characterization of lysine-methotrexate conjugate for enhanced brain delivery. Drug Deliv. 2016 Sep;23(7):2327-2337. Epub 2014 Dec 5. PubMed PMID: 25475953.

2: Díaz E, Köhidai L, Ríos A, Vanegas O, Silva A, Szabó R, Mező G, Hudecz F, Ponte-Sucre A. Leishmania braziliensis: cytotoxic, cytostatic and chemotactic effects of poly-lysine-methotrexate-conjugates. Exp Parasitol. 2013 Sep;135(1):134-41. doi: 10.1016/j.exppara.2013.06.007. Epub 2013 Jun 28. PubMed PMID: 23816643.

3: Kempton RJ, Black AM, Anstead GM, Kumar AA, Blankenship DT, Freisheim JH. Lysine and ornithine analogues of methotrexate as inhibitors of dihydrofolate reductase. J Med Chem. 1982 Apr;25(4):475-7. PubMed PMID: 7069726.